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Hmces Gene Detail
Summary
  • Symbol
    Hmces
  • Name
    5-hydroxymethylcytosine (hmC) binding, ES cell specific
  • Synonyms
    8430410A17Rik, Srap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914053
    NCBI Gene: 232210
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:87913935-87936629 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 39.13 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914053
protein coding gene Chr6:87913907-87936629 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031003
protein coding gene Chr6:89287261-89312452 (+)
A/J MGP_AJ_G0030969
protein coding gene Chr6:85843438-85866846 (+)
AKR/J MGP_AKRJ_G0030900
protein coding gene Chr6:88323145-88345841 (+)
BALB/cJ MGP_BALBcJ_G0030982
protein coding gene Chr6:85833400-85856116 (+)
C3H/HeJ MGP_C3HHeJ_G0030728
protein coding gene Chr6:96125080-96148719 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031439
protein coding gene Chr6:91674072-91697590 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028622
protein coding gene Chr6:84014021-84038047 (+)
CAST/EiJ MGP_CASTEiJ_G0030091
protein coding gene Chr6:88401820-88426448 (+)
CBA/J MGP_CBAJ_G0030666
protein coding gene Chr6:95222033-95244695 (+)
DBA/2J MGP_DBA2J_G0030822
protein coding gene Chr6:85138290-85160940 (+)
FVB/NJ MGP_FVBNJ_G0030775
protein coding gene Chr6:84329011-84352117 (+)
LP/J MGP_LPJ_G0030899
protein coding gene Chr6:89303633-89326139 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030808
protein coding gene Chr6:99354739-99378130 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031466
protein coding gene Chr6:88176688-88203185 (+)
PWK/PhJ MGP_PWKPhJ_G0029806
protein coding gene Chr6:84110223-84133232 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029634
protein coding gene Chr6:86986528-87010769 (+)
WSB/EiJ MGP_WSBEiJ_G0030172
protein coding gene Chr6:88624430-88651486 (+)



Homology
more
  • Human Ortholog
    HMCES, 5-hydroxymethylcytosine binding, ES cell specific
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HMCES, 5-hydroxymethylcytosine binding, ES cell specific
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C3orf37, DC12, SRAPD1
  • Links
    NCBI Gene ID: 56941
    neXtProt AC: NX_Q96FZ2
    UniProt: Q96FZ2

  • Chr Location
    3q21.3; chr3:129278806-129305293 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6636
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HMCES
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout leads to changes in DNA methylation, resulting in an altered embryonic gene expression profile and embryonic sub-lethality (lower embryonic survival).
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030060 Ensembl Gene Model | MGI Sequence Detail 22695 C57BL/6J ±  kb
transcript ENSMUST00000032141 Ensembl | MGI Sequence Detail 1464 Not Applicable  
polypeptide ENSMUSP00000032141 Ensembl | MGI Sequence Detail 353 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR036590 SOS response associated peptidase-like
    IPR003738 SOS response associated peptidase (SRAP)
Molecular
Reagents
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  • All nucleic 66
    cDNA 65
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141771
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:254234 Kweon SM, et al., Erasure of Tet-Oxidized 5-Methylcytosine by a SRAP Nuclease. Cell Rep. 2017 Oct 10;21(2):482-494

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory