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Hacd4 Gene Detail
Summary
  • Symbol
    Hacd4
  • Name
    3-hydroxyacyl-CoA dehydratase 4
  • Synonyms
    4933428I03Rik, Ptplad2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914025
    NCBI Gene: 66775
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:88407687-88438936 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 41.73 cM, cytoband C4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    268 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914025
protein coding gene Chr4:88396144-88438936 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028420
protein coding gene Chr4:88257848-88304709 (-)
A/J MGP_AJ_G0028381
protein coding gene Chr4:85186801-85230031 (-)
AKR/J MGP_AKRJ_G0028330
protein coding gene Chr4:87300219-87344104 (-)
BALB/cJ MGP_BALBcJ_G0028401
protein coding gene Chr4:85392323-85438942 (-)
C3H/HeJ MGP_C3HHeJ_G0028116
protein coding gene Chr4:88012638-88057675 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028840
protein coding gene Chr4:91635097-91681117 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026140
protein coding gene Chr4:81180101-81223367 (-)
CAST/EiJ MGP_CASTEiJ_G0027557
protein coding gene Chr4:85856880-85902103 (-)
CBA/J MGP_CBAJ_G0028085
protein coding gene Chr4:94463615-94509830 (-)
DBA/2J MGP_DBA2J_G0028234
protein coding gene Chr4:84943538-84986381 (-)
FVB/NJ MGP_FVBNJ_G0028200
protein coding gene Chr4:83906059-83948668 (-)
LP/J MGP_LPJ_G0028334
protein coding gene Chr4:88614171-88671991 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028229
protein coding gene Chr4:99454806-99503429 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028877
protein coding gene Chr4:87428000-87471731 (-)
PWK/PhJ MGP_PWKPhJ_G0027280
protein coding gene Chr4:83270898-83314542 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027105
protein coding gene Chr4:84932753-84981918 (-)
WSB/EiJ MGP_WSBEiJ_G0027633
protein coding gene Chr4:87633164-87676581 (-)



Homology
more
  • Human Ortholog
    HACD4, 3-hydroxyacyl-CoA dehydratase 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    HACD4, 3-hydroxyacyl-CoA dehydratase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PTPLAD2
  • Links
    NCBI Gene ID: 401494
    neXtProt AC: NX_Q5VWC8
    UniProt: Q5VWC8

  • Chr Location
    9p21.3; chr9:21003621-21031712 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12033
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HACD4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66775 NCBI Gene Model | MGI Sequence Detail 31250 C57BL/6J ±  kb
transcript NM_025760 RefSeq | MGI Sequence Detail 2089 C57BL/6  
polypeptide A2AKM2 UniProt | EBI | MGI Sequence Detail 232 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • EC
  • InterPro Domains
    IPR007482 Protein-tyrosine phosphatase-like, PTPLA
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:226931 Blondelle J, et al., HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth. J Mol Cell Biol. 2015 Oct;7(5):429-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory