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Emc2 Gene Detail
Summary
  • Symbol
    Emc2
  • Name
    ER membrane protein complex subunit 2
  • Synonyms
    4921531G14Rik, Ttc35
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913986
    NCBI Gene: 66736
  • Gene Overview
    MyGene.info: EMC2
Location & Maps
more
  • Sequence Map
    Chr15:43477229-43527777 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      50549 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 16.75 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EMC2, ER membrane protein complex subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EMC2, ER membrane protein complex subunit 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KIAA0103, TTC35
  • Links
    NCBI Gene ID: 9694
    neXtProt AC: NX_Q15006

  • Chr Location
    8q23.1; chr8:108443624-108486907 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8785
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: EMC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    2
  • Gene trapped
    16
  • Targeted
    2
  • Genomic Mutations
    2 involving Emc2
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022337 Ensembl Gene Model | MGI Sequence Detail 50549 C57BL/6J ±  kb
transcript ENSMUST00000022962 Ensembl | MGI Sequence Detail 1245 Not Applicable  
polypeptide ENSMUSP00000022962 Ensembl | MGI Sequence Detail 297 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    197 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000032774 ER membrane protein complex subunit 2
  • InterPro Domains
    IPR011990 Tetratricopeptide-like helical domain
    IPR019734 Tetratricopeptide repeat
    IPR013026 Tetratricopeptide repeat-containing domain
Molecular
Reagents
less
  • All nucleic 79
    cDNA 79

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146165, MGI:2146208
References
more
  • Summaries
    All 28
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory