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Emc2 Gene Detail
Summary
  • Symbol
    Emc2
  • Name
    ER membrane protein complex subunit 2
  • Synonyms
    4921531G14Rik, Ttc35
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913986
    NCBI Gene: 66736
  • Gene Overview
    MyGene.info: EMC2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:43477229-43527763 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 16.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913986
protein coding gene Chr15:43477229-43527777 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021826
protein coding gene Chr15:42074762-42118303 (+)
A/J MGP_AJ_G0021786
protein coding gene Chr15:40451344-40496384 (+)
AKR/J MGP_AKRJ_G0021767
protein coding gene Chr15:41662137-41703289 (+)
BALB/cJ MGP_BALBcJ_G0021793
protein coding gene Chr15:40530550-40576580 (+)
C3H/HeJ MGP_C3HHeJ_G0021567
protein coding gene Chr15:41560698-41615015 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022232
protein coding gene Chr15:43677482-43726454 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019769
protein coding gene Chr15:38041030-38083921 (+)
CAST/EiJ MGP_CASTEiJ_G0021084
protein coding gene Chr15:42100690-42143746 (+)
CBA/J MGP_CBAJ_G0021536
protein coding gene Chr15:45212543-45259738 (+)
DBA/2J MGP_DBA2J_G0021660
protein coding gene Chr15:40275098-40320438 (+)
FVB/NJ MGP_FVBNJ_G0021638
protein coding gene Chr15:39593800-39637165 (+)
LP/J MGP_LPJ_G0021730
protein coding gene Chr15:41862414-41904612 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021662
protein coding gene Chr15:48334925-48389196 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022255
protein coding gene Chr15:41839311-41884717 (+)
PWK/PhJ MGP_PWKPhJ_G0020829
protein coding gene Chr15:40316302-40446240 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020666
protein coding gene Chr15:41507991-41560899 (+)
WSB/EiJ MGP_WSBEiJ_G0021139
protein coding gene Chr15:41731714-41779737 (+)



Homology
more
  • Human Ortholog
    EMC2, ER membrane protein complex subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EMC2, ER membrane protein complex subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIAA0103, TTC35
  • Links
    NCBI Gene ID: 9694
    neXtProt AC: NX_Q15006
    UniProt: Q15006

  • Chr Location
    8q23.1; chr8:108443624-108486907 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8785
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EMC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022337 Ensembl Gene Model | MGI Sequence Detail 50535 C57BL/6J ±  kb
transcript ENSMUST00000022962 Ensembl | MGI Sequence Detail 1231 Not Applicable  
polypeptide ENSMUSP00000022962 Ensembl | MGI Sequence Detail 297 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 80
    cDNA 80

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146165, MGI:2146208
References
more
  • Summaries
    All 36
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory