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Tab3 Gene Detail
Summary
  • Symbol
    Tab3
  • Name
    TGF-beta activated kinase 1/MAP3K7 binding protein 3
  • Synonyms
    4921526G09Rik, Map3k7ip3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913974
    NCBI Gene: 66724
  • Gene Overview
    MyGene.info: TAB3
Location & Maps
more
  • Sequence Map
    ChrX:85574022-85634469 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      60448 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 39.32 cM, cytoband B
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TAB3, TGF-beta activated kinase 1/MAP3K7 binding protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TAB3, TGF-beta activated kinase 1/MAP3K7 binding protein 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MAP3K7IP3, NAP1
  • Links
    NCBI Gene ID: 257397
    neXtProt AC: NX_Q8N5C8

  • Chr Location
    Xp21.2; chrX:30827442-30889394 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotypes from multigenic genotypes
    14 images
    9 phenotype references
  • All Mutations and Alleles
    11
  • Gene trapped
    9
  • Targeted
    2
  • Incidental Mutations
    APF
Male chimeras hemizygous for a gene trapped allele appear normal at E9.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017925 VEGA Gene Model | MGI Sequence Detail 60448 C57BL/6J ±  kb
transcript OTTMUST00000043318 VEGA | MGI Sequence Detail 6364 Not Applicable  
polypeptide OTTMUSP00000019469 VEGA | MGI Sequence Detail 716 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    260 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000001771 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
  • PDB
  • InterPro Domains
    IPR003892 Ubiquitin system component Cue
    IPR001876 Zinc finger, RanBP2-type
Molecular
Reagents
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  • All nucleic 42
    cDNA 42

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:195289 Ori D, et al., Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs. J Immunol. 2013 Apr 15;190(8):4037-45

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory