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Actr2 Gene Detail
Summary
  • Symbol
    Actr2
  • Name
    actin related protein 2
  • Synonyms
    4921510D23Rik, Arp2, D6Ertd746e, MGC:36604
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913963
    NCBI Gene: 66713
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:20012304-20062913 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 12.88 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1569 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913963
 protein coding gene Chr11:20012304-20062951 (-)
129S1/SvImJ ENSMUSG00200021586
 protein coding gene Chr11:17022577-17073192 (-)
A/J ENSMUSG00195004833
 protein coding gene Chr11:16863300-16921850 (-)
AKR/J ENSMUSG00220002897
 protein coding gene Chr11:16952650-17011207 (-)
BALB/cJ ENSMUSG00180003921
 protein coding gene Chr11:16860669-16919221 (-)
C3H/HeJ ENSMUSG00175007545
 protein coding gene Chr11:16888453-16939063 (-)
C57BL/6NJ ENSMUSG00215003243
 protein coding gene Chr11:16951629-17002242 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016114
 protein coding gene Chr11:15980900-16030565 (-)
CAST/EiJ ENSTCUG00005006929
 protein coding gene Chr11:16835814-16886094 (-)
CBA/J ENSMUSG00210008802
 protein coding gene Chr11:16863143-16913748 (-)
DBA/2J ENSMUSG00185010754
 protein coding gene Chr11:16979860-17030469 (-)
FVB/NJ ENSMUSG00205004087
 protein coding gene Chr11:16904395-16962927 (-)
JF1/MsJ ENSUMUG00000004758
 protein coding gene Chr11:17160254-17217807 (-)
LP/J ENSMUSG00230004231
 protein coding gene Chr11:18010867-18069625 (-)
NOD/ShiLtJ ENSMUSG00190008206
 protein coding gene Chr11:16975039-17033575 (-)
NZO/HlLtJ ENSMUSG00225032791
 protein coding gene Chr11:20014883-20073652 (-)
PWK/PhJ ENSLUMG00010011276
 protein coding gene Chr11:16813508-16865312 (-)
SPRET/EiJ ENSMSPG00010017847
 protein coding gene Chr11:17102303-17152020 (-)
WSB/EiJ ENSIUOG00005009628
 protein coding gene Chr11:16927160-16977120 (-)



Homology
more
  • Human Ortholog
    ACTR2, actin related protein 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACTR2, actin related protein 2
  • Synonyms
    ARP2
  • Links
    NCBI Gene ID: 10097
    UniProt: P61160

  • Chr Location
    2p14; chr2:65227745-65271253 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    14 phenotype references
Mice heterozygous for this mutation exhibit modifies lethality associated with F5 null Tfpi heterozygous mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    2
  • cDNA Data
    16
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020152 Ensembl Gene Model | MGI Sequence Detail 50610 C57BL/6J ±  kb
transcript ENSMUST00000000137 Ensembl | MGI Sequence Detail 3631 Not Applicable  
polypeptide ENSMUSP00000000137 Ensembl | MGI Sequence Detail 394 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 18
    Primer pair 2
    Antibodies 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1289149, MGI:2144001
References
more
  • Summaries
    All 87
    Developmental Gene Expression 7
    Gene Ontology 13
    Phenotypes 14
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:391314 Mu J, et al., The mechanisms of DEPDC7-mediated actin cap establishment and meiosis progression in oocytes. EMBO Rep. 2026 Aug;27(15):4412-4432
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory