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Actr2 Gene Detail
Summary
  • Symbol
    Actr2
  • Name
    ARP2 actin-related protein 2
  • Synonyms
    4921510D23Rik, Arp2, D6Ertd746e, MGC:36604
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913963
    NCBI Gene: 66713
  • Gene Overview
    MyGene.info: ACTR2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:20062304-20112913 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 12.88 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    452 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913963
protein coding gene Chr11:20062304-20112951 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018063
protein coding gene Chr11:17544329-17602112 (-)
A/J MGP_AJ_G0018036
protein coding gene Chr11:16964328-17020277 (-)
AKR/J MGP_AKRJ_G0018000
protein coding gene Chr11:17577746-17636167 (-)
BALB/cJ MGP_BALBcJ_G0018004
protein coding gene Chr11:17088726-17143646 (-)
C3H/HeJ MGP_C3HHeJ_G0017818
protein coding gene Chr11:17466786-17518689 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018456
protein coding gene Chr11:18349174-18407751 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016114
protein coding gene Chr11:15980900-16030565 (-)
CAST/EiJ MGP_CASTEiJ_G0017379
protein coding gene Chr11:17434769-17486393 (-)
CBA/J MGP_CBAJ_G0017792
protein coding gene Chr11:19159679-19218660 (-)
DBA/2J MGP_DBA2J_G0017902
protein coding gene Chr11:16927406-16978591 (-)
FVB/NJ MGP_FVBNJ_G0017894
protein coding gene Chr11:16657589-16717268 (-)
LP/J MGP_LPJ_G0017973
protein coding gene Chr11:17727885-17791512 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017920
protein coding gene Chr11:19597181-19665177 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018497
protein coding gene Chr11:17655136-17710135 (-)
PWK/PhJ MGP_PWKPhJ_G0017159
protein coding gene Chr11:16890450-16970146 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016957
protein coding gene Chr11:17367081-17420531 (-)
WSB/EiJ MGP_WSBEiJ_G0017433
protein coding gene Chr11:17316750-17370934 (-)



Homology
more
  • Human Ortholog
    ACTR2, ARP2 actin related protein 2 homolog
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ACTR2, ARP2 actin related protein 2 homolog
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARP2
  • Links
    NCBI Gene ID: 10097
    neXtProt AC: NX_P61160
    UniProt: P61160

  • Chr Location
    2p14; chr2:65227695-65271253 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4181
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ACTR2
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    12 phenotype references
Mice heterozygous for this mutation exhibit modifies lethality associated with F5 null Tfpi heterozygous mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020152 Ensembl Gene Model | MGI Sequence Detail 50610 C57BL/6J ±  kb
transcript ENSMUST00000000137 Ensembl | MGI Sequence Detail 3631 Not Applicable  
polypeptide ENSMUSP00000000137 Ensembl | MGI Sequence Detail 394 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 18
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1289149, MGI:2144001
References
more
  • Summaries
    All 54
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 12
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:244506 Westrick RJ, et al., Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci. Proc Natl Acad Sci U S A. 2017 Sep 05;114(36):9659-9664

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory