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Spesp1
Gene Detail
Symbol

Name
ID
Spesp1
sperm equatorial segment protein 1
MGI:1913962
Synonyms
4921508E09Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 9
33.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:62270729-62282179 bp, - strand
From NCBI annotation of GRCm38

  11451 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49838  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Spesp1

Human
homologs
Human Homolog SPESP1, sperm equatorial segment protein 1
NCBI Gene ID 246777
neXtProt AC  NX_Q6UW49
Human Synonyms  ESP, SP-ESP
Human Chr (Location)  15q23; chr15:68930500-68946811 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Heterozygous and homozygous null mutant males show decreased fertilization frequency and delayed fertilization, otherwise homozygous null mice were healthy and showed no overt developmental abnormalities.
 
Interactions
Spesp1 interacts with 208 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process acrosome reaction, fusion of sperm to egg plasma membrane, ...
Component acrosomal vesicle, cell, ...
Function protein binding
External Resources: FuncBase
Expression
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000046846 (Evidence)
Entrez Gene66712 (Evidence)
UniGene263615
DFCITC1582581
DoTSDT.50316047
NIA Mouse Gene IndexU030978
Consensus CDS ProjectCCDS23263.1
International Mouse Knockout Project StatusSpesp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 66712 NCBI Gene Model | MGI Sequence Detail 11451 C57BL/6J ±  kb
transcript NM_025721 RefSeq | MGI Sequence Detail 3013 C57BL/6 
polypeptide Q9D5A0 UniProt | EBI | MGI Sequence Detail 399 Not Applicable 

For the selected sequences
All sequences(13) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026743 Sperm equatorial segment protein 1
Protein Ontology PR:000015516 sperm equatorial segment protein 1
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193640 Lo JC, et al., RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet. 2012;8(10):e1002969
All references(23)
Other
accession IDs
MGI:2143041

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory