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Rbm4b Gene Detail
Summary
  • Symbol
    Rbm4b
  • Name
    RNA binding motif protein 4B
  • Synonyms
    4921506I22Rik, Lark2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913954
    NCBI Gene: 66704
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4756497-4767065 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.11 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913954
protein coding gene Chr19:4752883-4767065 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024672
protein coding gene Chr19:1650334-1661190 (+)
A/J MGP_AJ_G0024638
protein coding gene Chr19:1574195-1584510 (+)
AKR/J MGP_AKRJ_G0024611
protein coding gene Chr19:1614916-1625641 (+)
BALB/cJ MGP_BALBcJ_G0024638
protein coding gene Chr19:1565626-1575922 (+)
C3H/HeJ MGP_C3HHeJ_G0024406
protein coding gene Chr19:1619208-1629915 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025085
protein coding gene Chr19:1698198-1712178 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022515
protein coding gene Chr19:1503878-1514169 (+)
CAST/EiJ MGP_CASTEiJ_G0023878
protein coding gene Chr19:1636158-1646760 (+)
CBA/J MGP_CBAJ_G0024377
protein coding gene Chr19:1773157-1786012 (+)
DBA/2J MGP_DBA2J_G0024505
protein coding gene Chr19:1536498-1547969 (+)
FVB/NJ MGP_FVBNJ_G0024472
protein coding gene Chr19:1562106-1572716 (+)
LP/J MGP_LPJ_G0024591
protein coding gene Chr19:1654170-1666506 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024502
protein coding gene Chr19:1678535-1692485 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025133
protein coding gene Chr19:1611539-1622246 (+)
PWK/PhJ MGP_PWKPhJ_G0023624
protein coding gene Chr19:1593029-1599264 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023429
protein coding gene Chr19:1602258-1612920 (+)
WSB/EiJ MGP_WSBEiJ_G0023940
protein coding gene Chr19:1607850-1619054 (+)



Homology
more
  • Human Ortholog
    RBM4B, RNA binding motif protein 4B
  • Vertebrate Orthologs
    11
  • Human Ortholog
    RBM4B, RNA binding motif protein 4B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RBM30, RBM4L, ZCCHC15, ZCCHC21B, ZCRB3B
  • Links
    NCBI Gene ID: 83759
    neXtProt AC: NX_Q9BQ04
    UniProt: Q9BQ04

  • Chr Location
    11q13.2; chr11:66664994-66677921 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 57033
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RBM4B
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit small pancreatic islets and defects in glucose metabolism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033760 Ensembl Gene Model | MGI Sequence Detail 10569 C57BL/6J ±  kb
    transcript ENSMUST00000235278 Ensembl | MGI Sequence Detail 1606 Not Applicable  
    polypeptide ENSMUSP00000157500 Ensembl | MGI Sequence Detail 357 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2147572, MGI:2147573
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:265269 D D, et al., RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development. Mol Cell Biol. 2018 Jun 15;38(12)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory