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Cpsf6 Gene Detail
Summary
  • Symbol
    Cpsf6
  • Name
    cleavage and polyadenylation specific factor 6
  • Synonyms
    4733401N12Rik, CFIM68, HPBRII-4, HPBRII-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913948
    NCBI Gene: 432508
  • Gene Overview
    MyGene.info: CPSF6
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:117344667-117376990 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 65.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    238 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913948
protein coding gene Chr10:117344667-117380015 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017759
protein coding gene Chr10:120245721-120282910 (-)
A/J MGP_AJ_G0017735
protein coding gene Chr10:115552607-115588403 (-)
AKR/J MGP_AKRJ_G0017697
protein coding gene Chr10:118934204-118970310 (-)
BALB/cJ MGP_BALBcJ_G0017698
protein coding gene Chr10:115952662-115987995 (-)
C3H/HeJ MGP_C3HHeJ_G0017523
protein coding gene Chr10:119168733-119204377 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018153
protein coding gene Chr10:124378856-124438714 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015834
protein coding gene Chr10:110110789-110145976 (-)
CAST/EiJ MGP_CASTEiJ_G0017083
protein coding gene Chr10:119458090-119493076 (-)
CBA/J MGP_CBAJ_G0017492
protein coding gene Chr10:129289308-129328949 (-)
DBA/2J MGP_DBA2J_G0017597
protein coding gene Chr10:114707653-114742970 (-)
FVB/NJ MGP_FVBNJ_G0017592
protein coding gene Chr10:113658660-113695194 (-)
LP/J MGP_LPJ_G0017670
protein coding gene Chr10:120817462-120854047 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017621
protein coding gene Chr10:132144753-132185133 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018193
protein coding gene Chr10:118998991-119035205 (-)
PWK/PhJ MGP_PWKPhJ_G0016867
protein coding gene Chr10:114803009-114839136 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016657
protein coding gene Chr10:117777942-117813281 (-)
WSB/EiJ MGP_WSBEiJ_G0017145
protein coding gene Chr10:119194703-119231092 (-)



Homology
more
  • Human Ortholog
    CPSF6, cleavage and polyadenylation specific factor 6
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CPSF6, cleavage and polyadenylation specific factor 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CFIM, CFIM68, CFIM72, HPBRII-4, HPBRII-7
  • Links
    NCBI Gene ID: 11052
    neXtProt AC: NX_Q16630
    UniProt: Q16630

  • Chr Location
    12q15; chr12:69239537-69274358 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 432508 NCBI Gene Model | MGI Sequence Detail 32324 C57BL/6J ±  kb
transcript NM_001310609 RefSeq | MGI Sequence Detail 6572 C57BL/6  
polypeptide Q6NVF9 UniProt | EBI | MGI Sequence Detail 551 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR034769 Cleavage and polyadenylation specificity factor subunit 6
    IPR034772 CPSF6/7 family
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
Molecular
Reagents
less
  • All nucleic 28
    cDNA 28

    Microarray probesets 10
Other
Accession IDs
less
MGI:2143549
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory