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Cpsf6 Gene Detail
Summary
  • Symbol
    Cpsf6
  • Name
    cleavage and polyadenylation specific factor 6
  • Synonyms
    4733401N12Rik, CFIM68, HPBRII-4, HPBRII-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913948
    NCBI Gene: 432508
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:117180572-117212903 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 65.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    708 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913948
 protein coding gene Chr10:117180572-117215920 (-)
129S1/SvImJ ENSMUSG00200024547
 protein coding gene Chr10:113600121-113623937 (-)
A/J ENSMUSG00195020179
 protein coding gene Chr10:114034854-114058727 (-)
AKR/J ENSMUSG00220014696
 protein coding gene Chr10:113608439-113632347 (-)
BALB/cJ ENSMUSG00180016241
 protein coding gene Chr10:114051747-114075619 (-)
C3H/HeJ ENSMUSG00175023463
 protein coding gene Chr10:113996991-114020814 (-)
C57BL/6NJ ENSMUSG00215013740
 protein coding gene Chr10:113693034-113716960 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015834
 protein coding gene Chr10:110110789-110145976 (-)
CAST/EiJ ENSTCUG00005029706
 protein coding gene Chr10:113003027-113026572 (-)
CBA/J ENSMUSG00210020703
 protein coding gene Chr10:113846587-113870409 (-)
DBA/2J ENSMUSG00185008015
 protein coding gene Chr10:113969626-113993502 (-)
FVB/NJ ENSMUSG00205019919
 protein coding gene Chr10:113295729-113319650 (-)
JF1/MsJ ENSUMUG00000018496
 protein coding gene Chr10:115258230-115281784 (-)
LP/J ENSMUSG00230024536
 protein coding gene Chr10:115919644-115943457 (-)
NOD/ShiLtJ ENSMUSG00190017911
 protein coding gene Chr10:114096209-114120076 (-)
NZO/HlLtJ ENSMUSG00225017316
 protein coding gene Chr10:120174727-120198644 (-)
PWK/PhJ ENSLUMG00010012453
 protein coding gene Chr10:113662558-113686323 (-)
SPRET/EiJ ENSMSPG00010015956
 protein coding gene Chr10:115601474-115624037 (-)
WSB/EiJ ENSIUOG00005013175
 protein coding gene Chr10:113689374-113713111 (-)



Homology
more
  • Human Ortholog
    CPSF6, cleavage and polyadenylation specific factor 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPSF6, cleavage and polyadenylation specific factor 6
  • Synonyms
    CFIM, CFIM68, CFIM72, HPBRII-4, HPBRII-7
  • Links
    NCBI Gene ID: 11052
    UniProt: Q16630

  • Chr Location
    12q15; chr12:69239543-69279829 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a null allele are infertile with no sperm in males. Bone marrow-derived macrophages show lower viral load and increased IFN-beta production after vesicular stomatitis virus infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    630
  • Tissues
    19
  • cDNA Data
    25
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 432508 NCBI Gene Model | MGI Sequence Detail 32332 C57BL/6J ±  kb
    transcript NM_001310609 RefSeq | MGI Sequence Detail 6572 C57BL/6  
    polypeptide Q6NVF9 UniProt | EBI | MGI Sequence Detail 551 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000005833 cleavage and polyadenylation specificity factor subunit 6
      (term hierarchy)
    • InterPro Domains
      IPR034769 Cleavage and polyadenylation specificity factor subunit 6, RNA recognition motif
      IPR034772 CPSF6/7
      IPR057951 CPSF6/7, RSLD domain, N-terminal region
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    • GlyGen
      Q6NVF9 3 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Primer pair 1
      Antibodies 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:2143549
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:353600 Liu X, et al., Dynamic regulation of alternative polyadenylation by PQBP1 during neurogenesis. Cell Rep. 2024 Aug 27;43(8):114525
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory