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Uqcrfs1
Gene Detail
 Symbol
Name
ID
Uqcrfs1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
MGI:1913944
Synonyms 4430402G14Rik
Feature Type protein coding gene
Genetic Map
Chromosome 13
13.23 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:30540308-30545362 bp, - strand
From VEGA annotation of GRCm38

  5055 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4378  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: ubiquinol-cytochrome-c reductase, iron-sulfur subunit
Gene Tree: Uqcrfs1

Human
homologs
Human Homolog UQCRFS1, ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
NCBI Gene ID 7386
neXtProt AC  NX_P47985
Human Synonyms  RIP1, RIS1, RISP, UQCR5
Human Chr (Location)  19q12; chr19:29207260-29213229 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant mice harboring a 3' UTR insertion that reduces expression specifically in skin acquire dark patches in the dorsal brown coat at 4-7 months of age. In heterozygotes, the dark patches eventually fill the entire dorsal region; in homozygotes, the dark patches eventually turn grey.
 
Interactions
Uqcrfs1 interacts with 62 markers (Mir16-2, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process oxidation-reduction process, transport
Component integral component of membrane, membrane, ...
Function 2 iron, 2 sulfur cluster binding, iron-sulfur cluster binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (97)    Tissues (96)    Images (6)
Theiler Stages: 22, 28
Assay TypeResults
RNA in situ 95
Western blot 2
cDNA source data(392)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(392) cDNA(392)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000000670 (Evidence)
Ensembl Gene ModelENSMUSG00000038462 (Evidence)
Entrez Gene66694 (Evidence)
UniGene181933
DFCITC1573351, TC1666800
DoTSDT.60118207, DT.94202649, DT.97382818, DT.97407027
NIA Mouse Gene IndexU034655, U138535
EC1.10.2.2
Consensus CDS ProjectCCDS26416.1
International Mouse Knockout Project StatusUqcrfs1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000670 VEGA Gene Model | MGI Sequence Detail 5055 C57BL/6J ±  kb
transcript OTTMUST00000001296 VEGA | MGI Sequence Detail 1363 Not Applicable 
polypeptide OTTMUSP00000000615 VEGA | MGI Sequence Detail 274 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011070 Globular protein, non-globular alpha/beta subunit
InterPro IPR017941 Rieske [2Fe-2S] iron-sulphur domain
InterPro IPR014349 Rieske iron-sulphur protein
InterPro IPR005805 Rieske iron-sulphur protein, C-terminal
InterPro IPR015248 Ubiquinol-cytochrome c reductase 8kDa, N-terminal
InterPro IPR006317 Ubiquinol-cytochrome c reductase, iron-sulphur subunit
InterPro IPR004192 Ubiquinol cytochrome reductase, transmembrane domain
Protein Ontology PR:000017126 cytochrome b-c1 complex subunit Rieske, mitochondrial
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193812 Sena LA, et al., Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling. Immunity. 2013 Feb 21;38(2):225-36
All references(46)
Other
accession IDs
MGI:2145312

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory