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Uqcrfs1 Gene Detail
Summary
  • Symbol
    Uqcrfs1
  • Name
    ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
  • Synonyms
    4430402G14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913944
    NCBI Gene: 66694
  • Gene Overview
    MyGene.info: UQCRFS1
Location & Maps
more
  • Sequence Map
    Chr13:30540308-30545362 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5055 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    UQCRFS1, ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    UQCRFS1, ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RIP1, RIS1, RISP, UQCR5
  • Links
    NCBI Gene ID: 7386
    neXtProt AC: NX_P47985

  • Chr Location
    19q12; chr19:29207260-29213229 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Uqcrfs1
  • Incidental Mutations
Mutant mice harboring a 3' UTR insertion that reduces expression specifically in skin acquire dark patches in the dorsal brown coat at 4-7 months of age. In heterozygotes, the dark patches eventually fill the entire dorsal region; in homozygotes, the dark patches eventually turn grey.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000670 VEGA Gene Model | MGI Sequence Detail 5055 C57BL/6J ±  kb
transcript OTTMUST00000001296 VEGA | MGI Sequence Detail 1363 Not Applicable  
polypeptide OTTMUSP00000000615 VEGA | MGI Sequence Detail 274 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    13 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000017126 cytochrome b-c1 complex subunit Rieske, mitochondrial
  • EC
  • InterPro Domains
    IPR011070 Globular protein, non-globular alpha/beta subunit
    IPR017941 Rieske [2Fe-2S] iron-sulphur domain
    IPR014349 Rieske iron-sulphur protein
    IPR005805 Rieske iron-sulphur protein, C-terminal
    IPR015248 Ubiquinol-cytochrome c reductase 8kDa, N-terminal
    IPR006317 Ubiquinol-cytochrome c reductase, iron-sulphur subunit
    IPR004192 Ubiquinol cytochrome reductase, transmembrane domain
Molecular
Reagents
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  • All nucleic 392
    cDNA 392

    Microarray probesets 2
Other
Accession IDs
less
MGI:2145312
References
more
  • Summaries
    All 43
    Developmental Gene Expression 3
    Gene Ontology 11
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:193812 Sena LA, et al., Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling. Immunity. 2013 Feb 21;38(2):225-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory