Uqcrfs1
Gene Detail

Symbol Name ID

Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 MGI:1913944

Synonyms

4430402G14Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 13

13.23 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr13:30540308-30545362 bp, - strand From VEGA annotation of GRCm38   5055 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4378  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: ubiquinol-cytochrome-c reductase, iron-sulfur subunit
Gene Tree: Uqcrfs1

Human homologs

Human Homolog		UQCRFS1, ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
NCBI Gene ID		7386
neXtProt AC		NX_P47985
Human Synonyms		RIP1, RIS1, RISP, UQCR5
Human Chr (Location)		19q12; chr19:29698167-29704136 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(2)
 

Mutant mice harboring a 3' UTR insertion that reduces expression specifically in skin acquire dark patches in the dorsal brown coat at 4-7 months of age. In heterozygotes, the dark patches eventually fill the entire dorsal region; in homozygotes, the dark patches eventually turn grey.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	electron transport chain, oxidation-reduction process, ...
Component	integral to membrane, membrane, ...
Function	2 iron, 2 sulfur cluster binding, iron-sulfur cluster binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (97)    Tissues (96)    Images (6)
Theiler Stages: 22, 28

Assay Type	Results
RNA in situ	95
Western blot	2

cDNA source data(388)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(388) cDNA(388)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000000670 (Evidence)
Ensembl Gene Model	ENSMUSG00000038462 (Evidence)
Entrez Gene	66694 (Evidence)
UniGene	181933
DFCI	TC1573351, TC1666800
DoTS	DT.60118207, DT.94202649, DT.97382818, DT.97407027
NIA Mouse Gene Index	U034655, U138535
EC	1.10.2.2
Consensus CDS Project	CCDS26416.1
International Mouse Knockout Project Status	Uqcrfs1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000670	VEGA Gene Model | MGI Sequence Detail	5055	C57BL/6J
transcript	OTTMUST00000001296	VEGA | MGI Sequence Detail	1363	Not Applicable
polypeptide	OTTMUSP00000000615	VEGA | MGI Sequence Detail	274	Not Applicable

All sequences(35) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(13 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011070	Globular protein, non-globular alpha/beta subunit
InterPro	IPR017941	Rieske [2Fe-2S] iron-sulphur domain
InterPro	IPR014349	Rieske iron-sulphur protein
InterPro	IPR005805	Rieske iron-sulphur protein, C-terminal
InterPro	IPR015248	Ubiquinol-cytochrome c reductase 8kDa, N-terminal
InterPro	IPR006317	Ubiquinol-cytochrome c reductase, iron-sulphur subunit
InterPro	IPR004192	Ubiquinol cytochrome reductase, transmembrane domain
Protein Ontology	PR:000017126	cytochrome b-c1 complex subunit Rieske, mitochondrial

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193812 Sena LA, et al., Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling. Immunity. 2013 Feb 21;38(2):225-36
All references(46)

Other accession IDs

MGI:2145312