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Tbc1d15 Gene Detail
Summary
  • Symbol
    Tbc1d15
  • Name
    TBC1 domain family, member 15
  • Synonyms
    4432405K22Rik, Ly6dl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913937
    NCBI Gene: 66687
  • Gene Overview
    MyGene.info: TBC1D15
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:115197872-115251467 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 63.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    520 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913937
protein coding gene Chr10:115197871-115251493 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017734
protein coding gene Chr10:117884990-117944519 (-)
A/J MGP_AJ_G0017710
protein coding gene Chr10:113368118-113424053 (-)
AKR/J MGP_AKRJ_G0017672
protein coding gene Chr10:116661045-116716963 (-)
BALB/cJ MGP_BALBcJ_G0017673
protein coding gene Chr10:113762872-113817480 (-)
C3H/HeJ MGP_C3HHeJ_G0017498
protein coding gene Chr10:116871064-116933065 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018130
protein coding gene Chr10:121987811-122045410 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015810
protein coding gene Chr10:107996533-108053509 (-)
CAST/EiJ MGP_CASTEiJ_G0017060
protein coding gene Chr10:117097239-117160896 (-)
CBA/J MGP_CBAJ_G0017467
protein coding gene Chr10:126741228-126799439 (-)
DBA/2J MGP_DBA2J_G0017572
protein coding gene Chr10:112520322-112574704 (-)
FVB/NJ MGP_FVBNJ_G0017567
protein coding gene Chr10:111466969-111520746 (-)
LP/J MGP_LPJ_G0017647
protein coding gene Chr10:118477447-118534479 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017596
protein coding gene Chr10:129705567-129763612 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018168
protein coding gene Chr10:116680630-116737415 (-)
PWK/PhJ MGP_PWKPhJ_G0016842
protein coding gene Chr10:112585868-112640100 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016632
protein coding gene Chr10:115485706-115544618 (-)
WSB/EiJ MGP_WSBEiJ_G0017120
protein coding gene Chr10:116857963-116914685 (-)



Homology
more
  • Human Ortholog
    TBC1D15, TBC1 domain family member 15
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TBC1D15, TBC1 domain family member 15
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RAB7-GAP
  • Links
    NCBI Gene ID: 64786
    neXtProt AC: NX_Q8TC07
    UniProt: Q8TC07

  • Chr Location
    12q21.1; chr12:71839707-71926849 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020130 Ensembl Gene Model | MGI Sequence Detail 53596 C57BL/6J ±  kb
transcript ENSMUST00000020339 Ensembl | MGI Sequence Detail 3752 Not Applicable  
polypeptide ENSMUSP00000020339 Ensembl | MGI Sequence Detail 671 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 243
    cDNA 243

    Microarray probesets 6
Other
Accession IDs
less
MGI:1913163, MGI:2143746, MGI:2143751, MGI:2143870
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:253317 Kwon D, et al., Stimulator of IFN genes-mediated DNA-sensing pathway is suppressed by NLRP3 agonists and regulated by mitofusin 1 and TBC1D15, mitochondrial dynamics mediators. FASEB J. 2017 Nov;31(11):4866-4878

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory