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Sorcs3 Gene Detail
Summary
  • Symbol
    Sorcs3
  • Name
    sortilin-related VPS10 domain containing receptor 3
  • Synonyms
    6330404A12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913923
    NCBI Gene: 66673
Location & Maps
more
  • Sequence Map
    Chr19:48206025-48805505 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      599481 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 41.32 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SORCS3, sortilin related VPS10 domain containing receptor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SORCS3, sortilin related VPS10 domain containing receptor 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SORCS
  • Links
    NCBI Gene ID: 22986
    neXtProt AC: NX_Q9UPU3

  • Chr Location
    10q23-q25; chr10:104640837-105265250 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8986
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SORCS3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit absent NMDA and glutamate receptor-dependent long term depression, impaired spatial learning and memory and impaired fear memory.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66673 NCBI Gene Model | MGI Sequence Detail 599481 C57BL/6J ±  kb
transcript NM_025696 RefSeq | MGI Sequence Detail 5634 C57BL/6  
polypeptide Q8VI51 UniProt | EBI | MGI Sequence Detail 1219 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    5439 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147683
References
more
  • Summaries
    All 25
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:217851 Oetjen S, et al., Spatiotemporal expression analysis of the growth factor receptor SorCS3. J Comp Neurol. 2014 Oct 15;522(15):3386-402

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory