Tmem268 Gene Detail

Summary

• Symbol
  Tmem268
• Name
  transmembrane protein 268
• Synonyms
  6330416G13Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1913920
  NCBI Gene: 230279
• Alliance
  gene page
• Transcription Start Sites
  11 TSS

Location &
Maps

• Sequence Map
  Chr4:63477018-63504594 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 4, 34.02 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  193 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913920	protein coding gene	Chr4:63472410-63504594 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028370	protein coding gene	Chr4:62576241-62603852 (+)
A/J	MGP_AJ_G0028331	protein coding gene	Chr4:60336282-60361855 (+)
AKR/J	MGP_AKRJ_G0028280	protein coding gene	Chr4:61973618-61995266 (+)
BALB/cJ	MGP_BALBcJ_G0028351	protein coding gene	Chr4:60513624-60540171 (+)
C3H/HeJ	MGP_C3HHeJ_G0028066	protein coding gene	Chr4:62495895-62517965 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028791	protein coding gene	Chr4:64724646-64753049 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026094	protein coding gene	Chr4:57680326-57704030 (+)
CAST/EiJ	MGP_CASTEiJ_G0027505	protein coding gene	Chr4:60491957-60516989 (+)
CBA/J	MGP_CBAJ_G0028035	protein coding gene	Chr4:66975916-67008805 (+)
DBA/2J	MGP_DBA2J_G0028184	protein coding gene	Chr4:60176941-60200909 (+)
FVB/NJ	MGP_FVBNJ_G0028150	protein coding gene	Chr4:59461877-59485973 (+)
LP/J	MGP_LPJ_G0028283	protein coding gene	Chr4:62871028-62896029 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028179	protein coding gene	Chr4:70093331-70117396 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028827	protein coding gene	Chr4:62083260-62108534 (+)
PWK/PhJ	MGP_PWKPhJ_G0027234	protein coding gene	Chr4:58724293-58748995 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027060	protein coding gene	Chr4:59566746-59590822 (+)
WSB/EiJ	MGP_WSBEiJ_G0027584	protein coding gene	Chr4:62114632-62141768 (+)

Homology

• Human Ortholog
  TMEM268, transmembrane protein 268

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TMEM268, transmembrane protein 268
  
• Synonyms
  C9orf91
• Links
  HGNC:24513

  NCBI Gene ID: 203197

  neXtProt AC: NX_Q5VZI3

  UniProt: Q5VZI3

  
  
• Chr Location
  9q32; chr9:114603904-114646422 (+)  GRCh38

---

• MGI Vertebrate Homology
  Tmem268 stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: TMEM268
• Gene Tree
  Tmem268
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotype references
  

• All Mutations and Alleles
  4
• Endonuclease-mediated
  2
• Targeted
  2
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  23 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  706
• cDNA Data
  10

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase tmem268

Sequences &
Gene Models

• All Sequences
  90
• RefSeq
  22
• UniProt
  3
• CCDS
  CCDS18261.1

• Ensembl
  ENSMUSG00000045917 (Evidence)
• NCBI Gene
  230279

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000045917	Ensembl Gene Model | MGI Sequence Detail	27577	C57BL/6J
transcript	ENSMUST00000077709	Ensembl | MGI Sequence Detail	3765	Not Applicable
polypeptide	ENSMUSP00000076891	Ensembl | MGI Sequence Detail	342	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000059845 transmembrane protein 268
  (term hierarchy)
• InterPro Domains
  IPR028054 Protein of unknown function DUF4481

Molecular
Reagents

• All nucleic 10

  cDNA 10

  
  

  Microarray probesets 5

Other
Accession IDs

MGI:2140577

References

• Summaries
  All 23

  Gene Ontology 1

  Phenotypes 3
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Tmem268:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37567	Chr4:63476695-63476740 (+)	-300 bp
Tssr37568	Chr4:63476985-63477096 (+)	23 bp
Tssr37569	Chr4:63477116-63477169 (+)	125 bp
Tssr37570	Chr4:63478425-63478436 (+)	1,413 bp
Tssr37571	Chr4:63478454-63478473 (+)	1,446 bp
Tssr37572	Chr4:63478478-63478503 (+)	1,473 bp
Tssr37573	Chr4:63478864-63478886 (+)	1,857 bp
Tssr37574	Chr4:63478890-63478897 (+)	1,876 bp
Tssr37575	Chr4:63478940-63478947 (+)	1,926 bp
Tssr37576	Chr4:63478953-63478977 (+)	1,947 bp
Tssr37577	Chr4:63498797-63498805 (+)	21,783 bp