Hspbap1 MGI Mouse Gene Detail - MGI:1913917

Symbol

Hspbap1
Name

Hspb associated protein 1
Synonyms

3830421G21Rik

Feature Type

protein coding gene
IDs

MGI:1913917
NCBI Gene: 66667
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr16:35590745-35648847 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 25.43 cM
Mapping Data

2 experiments

SNPs within 2kb

668 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913917	protein coding gene	Chr16:35590009-35648847 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022771	protein coding gene	Chr16:34107216-34169063 (+)
A/J	MGP_AJ_G0022736	protein coding gene	Chr16:32450937-32511642 (+)
AKR/J	MGP_AKRJ_G0022709	protein coding gene	Chr16:33586679-33647915 (+)
BALB/cJ	MGP_BALBcJ_G0022738	protein coding gene	Chr16:32579278-32640628 (+)
C3H/HeJ	MGP_C3HHeJ_G0022503	protein coding gene	Chr16:33724467-33784459 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023187	protein coding gene	Chr16:34842812-34906616 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020705	protein coding gene	Chr16:32817849-32875152 (+)
CAST/EiJ	MGP_CASTEiJ_G0022031	protein coding gene	Chr16:33944107-34004523 (+)
CBA/J	MGP_CBAJ_G0022473	protein coding gene	Chr16:36252707-36310625 (+)
DBA/2J	MGP_DBA2J_G0022606	protein coding gene	Chr16:32278501-32340393 (+)
FVB/NJ	MGP_FVBNJ_G0022581	protein coding gene	Chr16:32280271-32338551 (+)
LP/J	MGP_LPJ_G0022673	protein coding gene	Chr16:33842215-33906972 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022600	protein coding gene	Chr16:35537030-35598828 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023199	protein coding gene	Chr16:33651262-33713072 (+)
PWK/PhJ	MGP_PWKPhJ_G0021772	protein coding gene	Chr16:32679868-32738642 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021603	protein coding gene	Chr16:33444989-33507302 (+)
WSB/EiJ	MGP_WSBEiJ_G0022075	protein coding gene	Chr16:33574260-33634168 (+)

Human Ortholog

HSPBAP1, HSPB1 associated protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSPBAP1, HSPB1 associated protein 1
Synonyms

PASS1
Links

HGNC:16389

NCBI Gene ID: 79663

neXtProt AC: NX_Q96EW2

UniProt: Q96EW2
Chr Location

3q21.1; chr3:122739999-122793831 (-) GRCh38

MGI Vertebrate Homology

Hspbap1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HSPBAP1
Gene Tree

Hspbap1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

62
Endonuclease-mediated

1
Gene trapped

58
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

65 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

18
cDNA Data

34
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hspbap1

ZFIN hspbap1

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All Sequences

61
RefSeq

21
UniProt

2
CCDS

CCDS28142.1

Ensembl

ENSMUSG00000022849 (Evidence)
NCBI Gene

66667

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022849	Ensembl Gene Model \| MGI Sequence Detail	58103	C57BL/6J	± kb
transcript	ENSMUST00000231579	Ensembl \| MGI Sequence Detail	1703	Not Applicable
polypeptide	ENSMUSP00000156217	Ensembl \| MGI Sequence Detail	483	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008822 HSPB1-associated protein 1

(term hierarchy)
InterPro Domains

IPR041667 Cupin-like domain 8

IPR013296 HSPB1-associated protein 1

IPR003347 JmjC domain

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All nucleic 37

cDNA 36

Primer pair 1

Microarray probesets 7

Summaries

All 38

Developmental Gene Expression 4

Gene Ontology 2

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:313616 Zhang F, et al., Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice. Front Cell Dev Biol. 2021;9:642931

TSS for Hspbap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138222	Chr16:35590752-35590766 (+)	14 bp
Tssr138223	Chr16:35590768-35590797 (+)	38 bp
Tssr138224	Chr16:35596161-35596165 (+)	5,418 bp
Tssr138225	Chr16:35629439-35629453 (+)	38,701 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23