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Uba5 Gene Detail
Summary
  • Symbol
    Uba5
  • Name
    ubiquitin-like modifier activating enzyme 5
  • Synonyms
    5730525G14Rik, Ube1dc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913913
    NCBI Gene: 66663
  • Gene Overview
    MyGene.info: UBA5
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:104046599-104063134 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 56.28 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    167 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913913
protein coding gene Chr9:104046587-104063177 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035204
protein coding gene Chr9:105695001-105713635 (-)
A/J MGP_AJ_G0035184
protein coding gene Chr9:101897356-101913667 (-)
AKR/J MGP_AKRJ_G0035116
protein coding gene Chr9:104425611-104441951 (-)
BALB/cJ MGP_BALBcJ_G0035177
protein coding gene Chr9:101609321-101626073 (-)
C3H/HeJ MGP_C3HHeJ_G0034887
protein coding gene Chr9:104807663-104825555 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035697
protein coding gene Chr9:108618214-108635968 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032595
protein coding gene Chr9:99473150-99489111 (-)
CAST/EiJ MGP_CASTEiJ_G0034199
protein coding gene Chr9:104686003-104703230 (-)
CBA/J MGP_CBAJ_G0034856
protein coding gene Chr9:112389986-112406996 (-)
DBA/2J MGP_DBA2J_G0035017
protein coding gene Chr9:101381900-101398544 (-)
FVB/NJ MGP_FVBNJ_G0034965
protein coding gene Chr9:100185323-100201623 (-)
LP/J MGP_LPJ_G0035093
protein coding gene Chr9:105900743-105916956 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035004
protein coding gene Chr9:114165180-114182632 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035719
protein coding gene Chr9:104662238-104678552 (-)
PWK/PhJ MGP_PWKPhJ_G0033906
protein coding gene Chr9:101665166-101681289 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033741
protein coding gene Chr9:104743781-104760847 (-)
WSB/EiJ MGP_WSBEiJ_G0034319
protein coding gene Chr9:104538149-104555379 (-)



Homology
more
  • Human Ortholog
    UBA5, ubiquitin like modifier activating enzyme 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    UBA5, ubiquitin like modifier activating enzyme 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EIEE44, SCAR24, THIFP1, UBE1DC1
  • Links
    NCBI Gene ID: 79876
    neXtProt AC: NX_Q9GZZ9
    UniProt: Q9GZZ9

  • Chr Location
    3q22.1; chr3:132654446-132679786 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die at E12.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032557 Ensembl Gene Model | MGI Sequence Detail 16536 C57BL/6J ±  kb
transcript ENSMUST00000035166 Ensembl | MGI Sequence Detail 2404 Not Applicable  
polypeptide ENSMUSP00000035166 Ensembl | MGI Sequence Detail 403 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016953 ubiquitin-like modifier-activating enzyme 5
  • InterPro Domains
    IPR029752 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
    IPR000594 THIF-type NAD/FAD binding fold
    IPR035985 Ubiquitin-activating enzyme
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 7
Other
Accession IDs
less
MGI:2143304
References
more
  • Summaries
    All 30
    Gene Ontology 8
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:237644 Duan R, et al., UBA5 Mutations Cause a New Form of Autosomal Recessive Cerebellar Ataxia. PLoS One. 2016;11(2):e0149039

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory