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Brf2 Gene Detail
Summary
  • Symbol
    Brf2
  • Name
    BRF2, RNA polymerase III transcription initiation factor 50kDa subunit
  • Synonyms
    2700059M06Rik, 5730512K07Rik, BRFU, TFIIIB50
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913903
    NCBI Gene: 66653
  • Gene Overview
    MyGene.info: BRF2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:27123364-27128680 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 15.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913903
protein coding gene Chr8:27123339-27128699 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033502
protein coding gene Chr8:25311451-25316251 (-)
A/J MGP_AJ_G0033482
protein coding gene Chr8:24342658-24347458 (-)
AKR/J MGP_AKRJ_G0033407
protein coding gene Chr8:25146600-25151387 (-)
BALB/cJ MGP_BALBcJ_G0033478
protein coding gene Chr8:24501754-24506554 (-)
C3H/HeJ MGP_C3HHeJ_G0033192
protein coding gene Chr8:25368250-25373043 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033994
protein coding gene Chr8:26289993-26294793 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030944
protein coding gene Chr8:21594416-21599027 (-)
CAST/EiJ MGP_CASTEiJ_G0032518
protein coding gene Chr8:24855728-24860524 (-)
CBA/J MGP_CBAJ_G0033167
protein coding gene Chr8:27328381-27333181 (-)
DBA/2J MGP_DBA2J_G0033322
protein coding gene Chr8:24308565-24313804 (-)
FVB/NJ MGP_FVBNJ_G0033266
protein coding gene Chr8:24121433-24127980 (-)
LP/J MGP_LPJ_G0033411
protein coding gene Chr8:25263583-25268383 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033309
protein coding gene Chr8:26769333-26774189 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034013
protein coding gene Chr8:25130737-25135539 (-)
PWK/PhJ MGP_PWKPhJ_G0032229
protein coding gene Chr8:23968515-23975941 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032063
protein coding gene Chr8:24516734-24521519 (-)
WSB/EiJ MGP_WSBEiJ_G0032634
protein coding gene Chr8:25314666-25319470 (-)



Homology
more
  • Human Ortholog
    BRF2, BRF2, RNA polymerase III transcription initiation factor subunit
  • Vertebrate Orthologs
    12
  • Human Ortholog
    BRF2, BRF2, RNA polymerase III transcription initiation factor subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRFU, TFIIIB50
  • Links
    NCBI Gene ID: 55290
    neXtProt AC: NX_Q9HAW0
    UniProt: Q9HAW0

  • Chr Location
    8p11.23; chr8:37843880-37849913 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10127
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BRF2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031487 Ensembl Gene Model | MGI Sequence Detail 5317 C57BL/6J ±  kb
transcript ENSMUST00000033877 Ensembl | MGI Sequence Detail 1899 Not Applicable  
polypeptide ENSMUSP00000033877 Ensembl | MGI Sequence Detail 420 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR036915 Cyclin-like superfamily
    IPR000812 Transcription factor TFIIB
    IPR013137 Zinc finger, TFIIB-type
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 4
Other
Accession IDs
less
MGI:1919827, MGI:2142684, MGI:2142706
References
more
  • Summaries
    All 28
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory