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Nepn Gene Detail
Summary
  • Symbol
    Nepn
  • Name
    nephrocan
  • Synonyms
    5730521E12Rik, Npn, periolin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913900
    NCBI Gene: 66650
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:52388972-52404625 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 26.60 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913900
protein coding gene Chr10:52388864-52404625 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017225
protein coding gene Chr10:51546083-51563540 (+)
A/J MGP_AJ_G0017201
protein coding gene Chr10:50032045-50047654 (+)
AKR/J MGP_AKRJ_G0017160
protein coding gene Chr10:50984043-51010705 (+)
BALB/cJ MGP_BALBcJ_G0017162
protein coding gene Chr10:50132475-50148786 (+)
C3H/HeJ MGP_C3HHeJ_G0016984
protein coding gene Chr10:51239850-51255397 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017621
protein coding gene Chr10:53181293-53196812 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015315
protein coding gene Chr10:47252693-47268086 (+)
CAST/EiJ MGP_CASTEiJ_G0016558
protein coding gene Chr10:51362658-51379059 (+)
CBA/J MGP_CBAJ_G0016957
protein coding gene Chr10:55452379-55468314 (+)
DBA/2J MGP_DBA2J_G0017062
protein coding gene Chr10:49443148-49458588 (+)
FVB/NJ MGP_FVBNJ_G0017056
protein coding gene Chr10:48792919-48809154 (+)
LP/J MGP_LPJ_G0017137
protein coding gene Chr10:51625000-51640562 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017085
protein coding gene Chr10:57372609-57388929 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017656
protein coding gene Chr10:50923641-50941406 (+)
PWK/PhJ MGP_PWKPhJ_G0016339
protein coding gene Chr10:49304804-49322818 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016124
protein coding gene Chr10:50536617-50556082 (+)
WSB/EiJ MGP_WSBEiJ_G0016623
protein coding gene Chr10:51149966-51165432 (+)



Homology
more
  • Human Ortholog
    NEPNP, nephrocan, pseudogene
  • Vertebrate Orthologs
    5
  • Human Ortholog
    NEPNP, nephrocan, pseudogene
    Orthology source: HGNC
  • Synonyms
    NEPN, NPN
  • Links
    NCBI Gene ID: 442253

  • Chr Location
    6q22.1; chr6:117602928-117645087 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038624 Ensembl Gene Model | MGI Sequence Detail 15654 C57BL/6J ±  kb
    transcript ENSMUST00000067085 Ensembl | MGI Sequence Detail 1844 Not Applicable  
    polypeptide ENSMUSP00000070130 Ensembl | MGI Sequence Detail 512 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 18
      Primer pair 8
      Other 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 16
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:284817 Addeo M, et al., Insight into Nephrocan Function in Mouse Endoderm Patterning. Int J Mol Sci. 2019 Dec 18;21(1)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    07/29/2020
    MGI 6.15
    The Jackson Laboratory