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Uba6 Gene Detail
Summary
  • Symbol
    Uba6
  • Name
    ubiquitin-like modifier activating enzyme 6
  • Synonyms
    5730469D23Rik, Ube1l2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913894
    NCBI Gene: 231380
  • Gene Overview
    MyGene.info: UBA6
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:86110720-86172743 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 43.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    326 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913894
protein coding gene Chr5:86109287-86172803 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029665
protein coding gene Chr5:86941497-87005605 (-)
A/J MGP_AJ_G0029633
protein coding gene Chr5:83383108-83446217 (-)
AKR/J MGP_AKRJ_G0029581
protein coding gene Chr5:86147113-86219639 (-)
BALB/cJ MGP_BALBcJ_G0029642
protein coding gene Chr5:84291261-84352685 (-)
C3H/HeJ MGP_C3HHeJ_G0029365
protein coding gene Chr5:86641756-86703114 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030096
protein coding gene Chr5:90525732-90595389 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027338
protein coding gene Chr5:79248455-79309296 (-)
CAST/EiJ MGP_CASTEiJ_G0028773
protein coding gene Chr5:85897469-85973185 (-)
CBA/J MGP_CBAJ_G0029334
protein coding gene Chr5:93420988-93499234 (-)
DBA/2J MGP_DBA2J_G0029479
protein coding gene Chr5:83557433-83619345 (-)
FVB/NJ MGP_FVBNJ_G0029440
protein coding gene Chr5:82517396-82577802 (-)
LP/J MGP_LPJ_G0029566
protein coding gene Chr5:87345095-87418116 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029468
protein coding gene Chr5:98234098-98337606 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030129
protein coding gene Chr5:85739899-85803616 (-)
PWK/PhJ MGP_PWKPhJ_G0028497
protein coding gene Chr5:82538595-82606181 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028331
protein coding gene Chr5:85083614-85155939 (-)
WSB/EiJ MGP_WSBEiJ_G0028854
protein coding gene Chr5:86073351-86143781 (-)



Homology
more
  • Human Ortholog
    UBA6, ubiquitin like modifier activating enzyme 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UBA6, ubiquitin like modifier activating enzyme 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    E1-L2, MOP-4, UBE1L2
  • Links
    NCBI Gene ID: 55236
    neXtProt AC: NX_A0AVT1
    UniProt: A0AVT1

  • Chr Location
    4q13.2; chr4:67615761-67701171 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10080
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: UBA6
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit early embryonic lethality. Mice homozygous for a conditional allele activated in neurons exhibit decreased weight, postnatal and premature lethality and altered social behavior and neuronal development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 231380 NCBI Gene Model | MGI Sequence Detail 62024 C57BL/6J ±  kb
    transcript NM_172712 RefSeq | MGI Sequence Detail 5101 C57BL/6  
    polypeptide Q8C7R4 UniProt | EBI | MGI Sequence Detail 1053 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000016955 ubiquitin-like modifier-activating enzyme 6
    • EC
    • InterPro Domains
      IPR000594 THIF-type NAD/FAD binding fold
      IPR035985 Ubiquitin-activating enzyme
      IPR019572 Ubiquitin-activating enzyme, catalytic cysteine domain
      IPR018075 Ubiquitin-activating enzyme E1
      IPR018965 Ubiquitin-activating enzyme E1, C-terminal
      IPR038252 Ubiquitin-activating enzyme E1, C-terminal domain superfamily
      IPR032418 Ubiquitin-activating enzyme E1, FCCH domain
      IPR032420 Ubiquitin-activating enzyme E1, four-helix bundle
      IPR000011 Ubiquitin/SUMO-activating enzyme E1
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 22
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2141058, MGI:2141159
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:224069 Lee JY, et al., Impairment of social behavior and communication in mice lacking the Uba6-dependent ubiquitin activation system. Behav Brain Res. 2015 Mar 15;281:78-85

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory