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Sike1 Gene Detail
Summary
  • Symbol
    Sike1
  • Name
    suppressor of IKBKE 1
  • Synonyms
    2810005O12Rik, 5730470L24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913891
    NCBI Gene: 66641
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:102995740-103003914 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 45.25 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913891
protein coding gene Chr3:102995708-103008459 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027687
protein coding gene Chr3:104237167-104249832 (+)
A/J MGP_AJ_G0027646
protein coding gene Chr3:100922602-100937317 (+)
AKR/J MGP_AKRJ_G0027612
protein coding gene Chr3:103407787-103420539 (+)
BALB/cJ MGP_BALBcJ_G0027659
protein coding gene Chr3:100695384-100708133 (+)
C3H/HeJ MGP_C3HHeJ_G0027388
protein coding gene Chr3:103725682-103738374 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028102
protein coding gene Chr3:108102958-108115709 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025443
protein coding gene Chr3:97067072-97080449 (+)
CAST/EiJ MGP_CASTEiJ_G0026845
protein coding gene Chr3:102840868-102853526 (+)
CBA/J MGP_CBAJ_G0027363
protein coding gene Chr3:111791562-111804235 (+)
DBA/2J MGP_DBA2J_G0027506
protein coding gene Chr3:100175638-100188295 (+)
FVB/NJ MGP_FVBNJ_G0027474
protein coding gene Chr3:98106663-98119414 (+)
LP/J MGP_LPJ_G0027613
protein coding gene Chr3:105568855-105581533 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027503
protein coding gene Chr3:117957344-117971744 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028157
protein coding gene Chr3:102913176-102926581 (+)
PWK/PhJ MGP_PWKPhJ_G0026571
protein coding gene Chr3:99915566-99928606 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026393
protein coding gene Chr3:101010074-101022852 (+)
WSB/EiJ MGP_WSBEiJ_G0026924
protein coding gene Chr3:103482040-103495741 (+)



Homology
more
  • Human Ortholog
    SIKE1, suppressor of IKBKE 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SIKE1, suppressor of IKBKE 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SIKE
  • Links
    NCBI Gene ID: 80143
    neXtProt AC: NX_Q9BRV8
    UniProt: Q9BRV8

  • Chr Location
    1p13.2; chr1:114769479-114780687 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32622
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SIKE1
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Sike1
  • Incidental Mutations
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66641 NCBI Gene Model | MGI Sequence Detail 8175 C57BL/6J ±  kb
transcript NM_025679 RefSeq | MGI Sequence Detail 2798 C57BL/6  
polypeptide Q9CPR7 UniProt | EBI | MGI Sequence Detail 207 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 9
Other
Accession IDs
less
MGI:1919901, MGI:2139715, MGI:2139805
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:239911 Deng KQ, et al., Suppressor of IKKvarepsilon is an essential negative regulator of pathological cardiac hypertrophy. Nat Commun. 2016 Jun 01;7:11432

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory