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Tsen15 Gene Detail
Summary
  • Symbol
    Tsen15
  • Name
    tRNA splicing endonuclease subunit 15
  • Synonyms
    5730449L18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913887
    NCBI Gene: 66637
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:152246486-152262433 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 64.75 cM, cytoband G2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    250 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913887
 protein coding gene Chr1:152246486-152262439 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016586
 protein coding gene Chr1:157136245-157151741 (-)
A/J MGP_AJ_G0016568
 protein coding gene Chr1:150798742-150814582 (-)
AKR/J MGP_AKRJ_G0016533
 protein coding gene Chr1:155454078-155474330 (-)
BALB/cJ MGP_BALBcJ_G0016528
 protein coding gene Chr1:151374440-151390941 (-)
C3H/HeJ MGP_C3HHeJ_G0016353
 protein coding gene Chr1:155564684-155587903 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016989
 protein coding gene Chr1:162571212-162588937 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014698
 protein coding gene Chr1:143121630-143136533 (-)
CAST/EiJ MGP_CASTEiJ_G0015932
 protein coding gene Chr1:155053408-155072464 (-)
CBA/J MGP_CBAJ_G0016327
 protein coding gene Chr1:168288856-168309646 (-)
DBA/2J MGP_DBA2J_G0016433
 protein coding gene Chr1:149828209-149844308 (-)
FVB/NJ MGP_FVBNJ_G0016431
 protein coding gene Chr1:148299828-148315354 (-)
LP/J MGP_LPJ_G0016504
 protein coding gene Chr1:158235023-158255398 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016457
 protein coding gene Chr1:175944000-175975605 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017025
 protein coding gene Chr1:155235244-155251192 (-)
PWK/PhJ MGP_PWKPhJ_G0015718
 protein coding gene Chr1:148823247-148839381 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015505
 protein coding gene Chr1:154053627-154071289 (-)
WSB/EiJ MGP_WSBEiJ_G0015995
 protein coding gene Chr1:155297636-155315134 (-)



Homology
more
  • Human Ortholog
    TSEN15, tRNA splicing endonuclease subunit 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSEN15, tRNA splicing endonuclease subunit 15
  • Synonyms
    C1orf19, PCH2F, sen15
  • Links
    NCBI Gene ID: 116461
    neXtProt AC: NX_Q8WW01
    UniProt: Q8WW01

  • Chr Location
    1q25.3; chr1:184051651-184123978 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TSEN15 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    34
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66637 NCBI Gene Model | MGI Sequence Detail 15948 C57BL/6J ±  kb
transcript NM_025677 RefSeq | MGI Sequence Detail 1147 C57BL/6  
polypeptide Q8R3W5 UniProt | EBI | MGI Sequence Detail 168 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016714 tRNA-splicing endonuclease subunit Sen15
    (term hierarchy)
  • InterPro Domains
    IPR011856 tRNA endonuclease-like domain superfamily
    IPR036167 tRNA intron endonuclease, catalytic domain-like superfamily
    IPR018593 tRNA-splicing endonuclease subunit Sen15
Molecular
Reagents
less
  • All nucleic 34
    cDNA 34

    Microarray probesets 4
References
more
  • Summaries
    All 29
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory