About   Help   FAQ
Atat1 Gene Detail
Summary
  • Symbol
    Atat1
  • Name
    alpha tubulin acetyltransferase 1
  • Synonyms
    0610011P08Rik, 2610008K08Rik, 2610110G12Rik, 3110080J08Rik, MEC-17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913869
    NCBI Gene: 73242
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:36208487-36220967 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.75 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913869
 protein coding gene Chr17:36208487-36220971 (-)
129S1/SvImJ ENSMUSG00200048838
 protein coding gene Chr17:31833840-31846320 (-)
A/J ENSMUSG00195043167
 protein coding gene Chr17:32895726-32908209 (-)
AKR/J ENSMUSG00220050334
 protein coding gene Chr17:31697219-31709702 (-)
BALB/cJ ENSMUSG00180033522
 protein coding gene Chr17:32265520-32278003 (-)
C3H/HeJ ENSMUSG00175026712
 protein coding gene Chr17:31583055-31595534 (-)
C57BL/6NJ ENSMUSG00215050551
 protein coding gene Chr17:31659059-31671539 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021540
 protein coding gene Chr17:32673280-32685737 (-)
CAST/EiJ ENSTCUG00005040349
 protein coding gene Chr17:32725274-32737741 (-)
CBA/J ENSMUSG00210039486
 protein coding gene Chr17:31405114-31417594 (-)
DBA/2J ENSMUSG00185049962
 protein coding gene Chr17:34284668-34297151 (-)
FVB/NJ ENSMUSG00205039326
 protein coding gene Chr17:31951744-31964164 (-)
JF1/MsJ ENSUMUG00000035349
 protein coding gene Chr17:33240631-33253073 (-)
LP/J ENSMUSG00230054567
 protein coding gene Chr17:35322511-35334991 (-)
NOD/ShiLtJ ENSMUSG00190043447
 protein coding gene Chr17:31570860-31583280 (-)
NZO/HlLtJ ENSMUSG00225053374
 protein coding gene Chr17:37398949-37411414 (-)
PWK/PhJ ENSLUMG00010043079
 protein coding gene Chr17:31203659-31216116 (-)
SPRET/EiJ ENSMSPG00010049628
 protein coding gene Chr17:32421018-32433100 (-)
WSB/EiJ ENSIUOG00005043981
 protein coding gene Chr17:32387971-32400426 (-)



Homology
more
  • Human Ortholog
    ATAT1, alpha tubulin acetyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATAT1, alpha tubulin acetyltransferase 1
  • Synonyms
    alpha-TAT, alpha-TAT1, C6orf134, MEC17, Nbla00487
  • Links
    NCBI Gene ID: 79969
    UniProt: Q5SQI0

  • Chr Location
    6p21.33; chr6:30626842-30646835 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired alpha tubulin acetylation and abnormal dentate gyrus morphology. Mice homozygous for a different knock-out allele exhibit reduced male fertility associated with teratozoospermia, oligozoospermia andasthenozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    48
  • cDNA Data
    100
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024426 Ensembl Gene Model | MGI Sequence Detail 12481 C57BL/6J ±  kb
    transcript ENSMUST00000061052 Ensembl | MGI Sequence Detail 1452 Not Applicable  
    polypeptide ENSMUSP00000056383 Ensembl | MGI Sequence Detail 421 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      cDNA 102
      Primer pair 10
      Antibodies 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915603, MGI:1917147, MGI:1920492
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 11
      Gene Ontology 18
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:365383 Short KL, et al., Disrupted glucocorticoid receptor cell signalling causes a ciliogenesis defect in the fetal mouse renal tubule. EMBO Rep. 2025 Apr 17;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory