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Atg4b Gene Detail
Summary
  • Symbol
    Atg4b
  • Name
    autophagy related 4B, cysteine peptidase
  • Synonyms
    2510009N07Rik, Apg4b, autophagin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913865
    NCBI Gene: 66615
  • Gene Overview
    MyGene.info: ATG4B
Location & Maps
more
  • Sequence Map
    Chr1:93751500-93790610 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39111 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 47.32 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ATG4B, autophagy related 4B cysteine peptidase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATG4B, autophagy related 4B cysteine peptidase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APG4B, AUTL1
  • Links
    NCBI Gene ID: 23192
    neXtProt AC: NX_Q9Y4P1

  • Chr Location
    2q37.3; chr2:241637612-241673857 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Gene trapped
    13
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Atg4b
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit decreased autophagy, impaired swimming, circling, head tilting, and abnormal utricle, saccular, and otolith morphology. Mice homozygous for another gene trap allele exhibit partial preweaning lethality and impaired motor coordination and learning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032629 VEGA Gene Model | MGI Sequence Detail 39111 C57BL/6J ±  kb
transcript OTTMUST00000081166 VEGA | MGI Sequence Detail 4173 Not Applicable  
polypeptide OTTMUSP00000043366 VEGA | MGI Sequence Detail 393 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    73 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 6
Other
Accession IDs
less
MGI:2138547
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228300 Kimmey JM, et al., Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection. Nature. 2015 Dec 24;528(7583):565-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory