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Gemin2 Gene Detail
Summary
  • Symbol
    Gemin2
  • Name
    gem nuclear organelle associated protein 2
  • Synonyms
    1700012N19Rik, Sip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913853
    NCBI Gene: 66603
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:59013393-59028470 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 25.99 cM, cytoband C2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    165 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913853
protein coding gene Chr12:59013391-59028470 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019766
protein coding gene Chr12:58207223-58222276 (+)
A/J MGP_AJ_G0019725
protein coding gene Chr12:56094595-56109626 (+)
AKR/J MGP_AKRJ_G0019700
protein coding gene Chr12:57876620-57891723 (+)
BALB/cJ MGP_BALBcJ_G0019705
protein coding gene Chr12:56475853-56491091 (+)
C3H/HeJ MGP_C3HHeJ_G0019510
protein coding gene Chr12:57975125-57991226 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020157
protein coding gene Chr12:59912857-59929543 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017777
protein coding gene Chr12:54467456-54483961 (+)
CAST/EiJ MGP_CASTEiJ_G0019062
protein coding gene Chr12:52863838-52883440 (+)
CBA/J MGP_CBAJ_G0019479
protein coding gene Chr12:62123133-62143340 (+)
DBA/2J MGP_DBA2J_G0019595
protein coding gene Chr12:56009306-56024362 (+)
FVB/NJ MGP_FVBNJ_G0019583
protein coding gene Chr12:55279403-55294084 (+)
LP/J MGP_LPJ_G0019667
protein coding gene Chr12:58248014-58263754 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019621
protein coding gene Chr12:63729473-63746315 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020191
protein coding gene Chr12:57320329-57338553 (+)
PWK/PhJ MGP_PWKPhJ_G0018829
protein coding gene Chr12:50374898-50390942 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018622
protein coding gene Chr12:51721209-51736647 (+)
WSB/EiJ MGP_WSBEiJ_G0019113
protein coding gene Chr12:57886911-57901915 (+)



Homology
more
  • Human Ortholog
    GEMIN2, gem nuclear organelle associated protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GEMIN2, gem nuclear organelle associated protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SIP1, SIP1-delta
  • Links
    NCBI Gene ID: 8487
    neXtProt AC: NX_O14893
    UniProt: O14893

  • Chr Location
    14q21.1; chr14:39114261-39136973 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    29
  • Chemically induced (other)
    1
  • Gene trapped
    26
  • Targeted
    2
  • Genomic Mutations
    1 involving Gemin2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for disruptions in this gene die as embryos.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000060121 Ensembl Gene Model | MGI Sequence Detail 15078 C57BL/6J ±  kb
transcript ENSMUST00000021379 Ensembl | MGI Sequence Detail 1588 Not Applicable  
polypeptide ENSMUSP00000021379 Ensembl | MGI Sequence Detail 269 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 22
    Primer pair 2

    Microarray probesets 4
References
more
  • Summaries
    All 42
    Developmental Gene Expression 10
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:182704 Weng Q, et al., Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system. Neuron. 2012 Feb 23;73(4):713-28

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory