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Mgst1 Gene Detail
Summary
  • Symbol
    Mgst1
  • Name
    microsomal glutathione S-transferase 1
  • Synonyms
    1500002K10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913850
    NCBI Gene: 56615
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:138140537-138156755 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 68.40 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    332 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913850
protein coding gene Chr6:138140316-138156755 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031440
protein coding gene Chr6:142708901-142725550 (+)
A/J MGP_AJ_G0031415
protein coding gene Chr6:137085620-137102336 (+)
AKR/J MGP_AKRJ_G0031343
protein coding gene Chr6:141257003-141274377 (+)
BALB/cJ MGP_BALBcJ_G0031422
protein coding gene Chr6:136942263-136961495 (+)
C3H/HeJ MGP_C3HHeJ_G0031144
protein coding gene Chr6:141270154-141288543 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031884
protein coding gene Chr6:146567846-146584891 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029013
protein coding gene Chr6:136105022-136122685 (+)
CAST/EiJ MGP_CASTEiJ_G0030512
protein coding gene Chr6:140770068-140792208 (+)
CBA/J MGP_CBAJ_G0031104
protein coding gene Chr6:152174439-152193718 (+)
DBA/2J MGP_DBA2J_G0031261
protein coding gene Chr6:135936846-135955896 (+)
FVB/NJ MGP_FVBNJ_G0031212
protein coding gene Chr6:134805409-134821772 (+)
LP/J MGP_LPJ_G0031345
protein coding gene Chr6:142847685-142864024 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031252
protein coding gene Chr6:155971319-155993629 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031916
protein coding gene Chr6:140988755-141005350 (+)
PWK/PhJ MGP_PWKPhJ_G0030239
protein coding gene Chr6:134423160-134440438 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030063
protein coding gene Chr6:139240391-139257825 (+)
WSB/EiJ MGP_WSBEiJ_G0030605
protein coding gene Chr6:141631632-141651977 (+)



Homology
more
  • Human Ortholog
    MGST1, microsomal glutathione S-transferase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MGST1, microsomal glutathione S-transferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GST12, MGST, MGST-I
  • Links
    NCBI Gene ID: 4257
    neXtProt AC: NX_P10620
    UniProt: P10620

  • Chr Location
    12p12.3; chr12:16347142-16377189 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56615 NCBI Gene Model | MGI Sequence Detail 16219 C57BL/6J ±  kb
transcript NM_001347489 RefSeq | MGI Sequence Detail 1172 C57BL/6  
polypeptide Q91VS7 UniProt | EBI | MGI Sequence Detail 155 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • EC
  • InterPro Domains
    IPR023352 Membrane associated eicosanoid/glutathione metabolism-like domain superfamily
    IPR001129 Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
Molecular
Reagents
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  • All nucleic 698
    cDNA 698

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Developmental Gene Expression 8
    Gene Ontology 8
    Phenotypes 2
  • Earliest
    J:61967 Raza H, et al., Cloning, characterisation and bacterial expression of full length cDNA for the mouse liver microsomal glutathione S-transferase. Oncol Rep. 2000 May-Jun;7(3):645-9
  • Latest
    J:257520 Sardella C, et al., Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion. J Invest Dermatol. 2018 Mar;138(3):500-510

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory