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Trim13 Gene Detail
Summary
  • Symbol
    Trim13
  • Name
    tripartite motif-containing 13
  • Synonyms
    3110001L12Rik, LEU5, Rfp2, RNF77
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913847
    NCBI Gene: 66597
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:61835696-61843395 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 33.16 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913847
protein coding gene Chr14:61835675-61847736 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J MGP_AKRJ_G0021377
protein coding gene Chr14:56715020-56722707 (+)
BALB/cJ MGP_BALBcJ_G0021407
protein coding gene Chr14:54721499-54728703 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0021846
protein coding gene Chr14:58712042-58719762 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019386
protein coding gene Chr14:52738751-52746550 (+)
CAST/EiJ MGP_CASTEiJ_G0020701
protein coding gene Chr14:52746541-52756001 (+)
CBA/J MGP_CBAJ_G0019380
protein coding gene Chr12:31252644-31253537 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0021253
protein coding gene Chr14:53850441-53857647 (+)
LP/J MGP_LPJ_G0021349
protein coding gene Chr14:57019282-57028468 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021282
protein coding gene Chr14:59707379-59716825 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021869
protein coding gene Chr14:55864390-55872116 (+)
PWK/PhJ MGP_PWKPhJ_G0020445
protein coding gene Chr14:51095743-51104305 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020278
protein coding gene Chr14:51791228-51799520 (+)
WSB/EiJ MGP_WSBEiJ_G0020754
protein coding gene Chr14:56182900-56191461 (+)



Homology
more
  • Human Ortholog
    TRIM13, tripartite motif containing 13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM13, tripartite motif containing 13
  • Synonyms
    CAR, DLEU5, LEU5, RFP2, RNF77
  • Links
    NCBI Gene ID: 10206
    neXtProt AC: NX_O60858
    UniProt: O60858

  • Chr Location
    13q14.2; chr13:49995888-50020481 (+)  GRCh38

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased lethality induced by EMCV infection and altered type I IFN production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035235 Ensembl Gene Model | MGI Sequence Detail 7700 C57BL/6J ±  kb
    transcript ENSMUST00000039562 Ensembl | MGI Sequence Detail 1550 Not Applicable  
    polypeptide ENSMUSP00000045009 Ensembl | MGI Sequence Detail 407 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 1
      cDNA 26
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 5
      Phenotypes 20
    • Earliest
      J:66949 Kapanadze B, et al., Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in b-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14. Genomics. 2000 Dec 15;70(3):327-34
    • Latest
      J:329154 Li X, et al., The transmembrane endoplasmic reticulum-associated E3 ubiquitin ligase TRIM13 restrains the pathogenic-DNA-triggered inflammatory response. Sci Adv. 2022 Jan 28;8(4):eabh0496

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory