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Farsa Gene Detail
Summary
  • Symbol
    Farsa
  • Name
    phenylalanyl-tRNA synthetase, alpha subunit
  • Synonyms
    0610012A19Rik, Farsla
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913840
    NCBI Gene: 66590
  • Gene Overview
    MyGene.info: FARSA
Location & Maps
more
  • Sequence Map
    Chr8:84856989-84869257 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12269 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FARSA, phenylalanyl-tRNA synthetase alpha subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FARSA, phenylalanyl-tRNA synthetase alpha subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CML33, FARSL, FARSLA, FRSA, PheHA
  • Links
    NCBI Gene ID: 2193
    neXtProt AC: NX_Q9Y285

  • Chr Location
    19p13.2; chr19:12922470-12933744 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    1
  • Gene trapped
    16
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Farsa
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022260 VEGA Gene Model | MGI Sequence Detail 12269 C57BL/6J ±  kb
transcript OTTMUST00000052994 VEGA | MGI Sequence Detail 1826 Not Applicable  
polypeptide OTTMUSP00000025176 VEGA | MGI Sequence Detail 508 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    97 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000007346 phenylalanine--tRNA ligase alpha subunit
  • EC
  • InterPro Domains
    IPR006195 Aminoacyl-tRNA synthetase, class II
    IPR013196 Helix-turn-helix, type 11
    IPR002319 Phenylalanyl-tRNA synthetase
    IPR004529 Phenylalanyl-tRNA synthetase, class IIc, alpha subunit
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 116
    cDNA 116

    Microarray probesets 5
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 36
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory