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Fastk Gene Detail
Summary
  • Symbol
    Fastk
  • Name
    Fas-activated serine/threonine kinase
  • Synonyms
    0610011K02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913837
    NCBI Gene: 66587
  • Gene Overview
    MyGene.info: FASTK
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:24441039-24445282 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 11.78 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913837
protein coding gene Chr5:24438440-24445287 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029344
protein coding gene Chr5:22166107-22172953 (-)
A/J MGP_AJ_G0029310
protein coding gene Chr5:21411252-21418099 (-)
AKR/J MGP_AKRJ_G0029261
protein coding gene Chr5:22272709-22279555 (-)
BALB/cJ MGP_BALBcJ_G0029321
protein coding gene Chr5:21924346-21931193 (-)
C3H/HeJ MGP_C3HHeJ_G0029041
protein coding gene Chr5:22386954-22393801 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029774
protein coding gene Chr5:23659448-23666295 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027012
protein coding gene Chr5:19353485-19360339 (-)
CAST/EiJ MGP_CASTEiJ_G0028453
protein coding gene Chr5:21559965-21566812 (-)
CBA/J MGP_CBAJ_G0029008
protein coding gene Chr5:24047351-24054198 (-)
DBA/2J MGP_DBA2J_G0029159
protein coding gene Chr5:21704317-21711167 (-)
FVB/NJ MGP_FVBNJ_G0029117
protein coding gene Chr5:21073574-21080421 (-)
LP/J MGP_LPJ_G0029243
protein coding gene Chr5:22570873-22577719 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029146
protein coding gene Chr5:25169981-25176828 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029808
protein coding gene Chr5:21915268-21922115 (-)
PWK/PhJ MGP_PWKPhJ_G0028177
protein coding gene Chr5:20782544-20789394 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028008
protein coding gene Chr5:21270580-21277383 (-)
WSB/EiJ MGP_WSBEiJ_G0028533
protein coding gene Chr5:21983536-21990383 (-)



Homology
more
  • Human Ortholog
    FASTK, Fas activated serine/threonine kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FASTK, Fas activated serine/threonine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FAST
  • Links
    NCBI Gene ID: 10922
    neXtProt AC: NX_Q14296
    UniProt: Q14296

  • Chr Location
    7q36.1; chr7:151076621-151080883 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele lack neutophil infiltration in a model of house dust mite induced allergic pulmonary inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66587 NCBI Gene Model | MGI Sequence Detail 4244 C57BL/6J ±  kb
transcript NM_023229 RefSeq | MGI Sequence Detail 1840 C57BL/6  
polypeptide Q9JIX9 UniProt | EBI | MGI Sequence Detail 511 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 113
    cDNA 112
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 47
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 6
    Phenotypes 19
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:236757 West DB, et al., Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. PLoS Genet. 2016 Feb;12(2):e1005691

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory