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Fastk
Gene Detail
Symbol

Name
ID
Fastk
Fas-activated serine/threonine kinase
MGI:1913837
Synonyms
0610011K02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 5
11.78 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:24438440-24445287 bp, - strand
From VEGA annotation of GRCm38

  6848 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4884  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: FASTK
Protein SuperFamily: Fas-activated serine/threonine kinase
Gene Tree: Fastk

Human
homologs
FASTK, Fas-activated serine/threonine kinase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10922
neXtProt AC: NX_Q14296

Human Synonyms: FAST

Human Chr (Location): 7q35; chr7:151076620-151080883 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele lack neutophil infiltration in a model of house dust mite induced allergic pulmonary inflammation.
 
Interactions
Fastk interacts with 230 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process apoptotic process, phosphorylation, ...
Component mitochondrion, nuclear speck
Function ATP binding, Fas-activated serine/threonine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 2
cDNA source data(111)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(112) cDNA(111) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000024187 (Evidence)
Ensembl Gene Model ENSMUSG00000028959 (Evidence)
Entrez Gene 66587 (Evidence)
UniGene 28123
DFCI TC1572141
DoTS DT.91319863, DT.535025, DT.94283223, DT.101403539, DT.110632684, DT.97344606, DT.97382760
NIA Mouse Gene Index U025995
EC 2.7.11.8
Consensus CDS Project CCDS19120.1
International Mouse Phenotyping Consortium Status Fastk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024187 VEGA Gene Model | MGI Sequence Detail 6848 C57BL/6J ±  kb
transcript OTTMUST00000059171 VEGA | MGI Sequence Detail 1893 Not Applicable 
polypeptide OTTMUSP00000028758 VEGA | MGI Sequence Detail 545 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(5) UniProt(8)
Polymorphisms
SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015715 Fas activated serine/threonine kinase FAST
InterPro IPR010622 FAST kinase leucine-rich
InterPro IPR013579 FAST kinase-like protein, subdomain 2
InterPro IPR013584 RAP domain
Protein Ontology PR:000007349 Fas-activated serine/threonine kinase
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory