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Exosc1
Gene Detail
 Symbol
Name
ID
Exosc1
exosome component 1
MGI:1913833
Synonyms 2610035C18Rik, 2610104C07Rik, 2610312F07Rik
Feature Type protein coding gene
Genetic Map
Chromosome 19
35.46 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:41922980-41933314 bp, - strand
From NCBI annotation of GRCm38

  10335 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9359  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 3'-5' exoribonuclease CSL4 homolog
Gene Tree: Exosc1

Human
homologs
Human Homolog EXOSC1, exosome component 1
NCBI Gene ID 51013
neXtProt AC  NX_Q9Y3B2
Human Synonyms  CGI-108, CSL4, Csl4p, hCsl4p, p13, SKI4, Ski4p
Human Chr (Location)  10q24; chr10:97435909-97446051 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(10) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Exosc1 interacts with 119 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process RNA processing, rRNA processing
Component cytoplasm, exosome (RNase complex), ...
Function protein binding, RNA binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (9)    Tissues (1)    Images (9)
Theiler Stages: 23
Assay TypeResults
RNA in situ 9
cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(50) cDNA(50)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000034321 (Evidence)
Entrez Gene66583 (Evidence)
UniGene289086
DFCITC1582046, TC1584517, TC1670147
NIA Mouse Gene IndexU039043
Consensus CDS ProjectCCDS29816.1, CCDS50436.1
International Mouse Knockout Project StatusExosc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 66583 NCBI Gene Model | MGI Sequence Detail 10335 C57BL/6J ±  kb
transcript NM_025644 RefSeq | MGI Sequence Detail 1622 C57BL/6 
polypeptide Q9DAA6 UniProt | EBI | MGI Sequence Detail 195 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(8) UniProt(1)
Polymorphisms SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019495 Exosome complex component CSL4
InterPro IPR025721 Exosome complex component, N-terminal domain
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR022967 RNA-binding domain, S1
Protein Ontology PR:000007257 exosome complex component CSL4
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185743 Cotney J, et al., Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb. Genome Res. 2012 Jun;22(6):1069-80
All references(35)
Other
accession IDs
MGI:1913871, MGI:1914932, MGI:2147537

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory