About   Help   FAQ
Exosc1
Gene Detail
Symbol

Name
ID
Exosc1
exosome component 1
MGI:1913833
Synonyms
2610035C18Rik, 2610104C07Rik, 2610312F07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 19
35.46 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:41922980-41933314 bp, - strand
From Ensembl annotation of GRCm38

  10335 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9359  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EXOSC1
Protein SuperFamily: 3'-5' exoribonuclease CSL4 homolog
Gene Tree: Exosc1

Human
homologs
EXOSC1, exosome component 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51013
neXtProt AC: NX_Q9Y3B2

Human Synonyms: CGI-108, CSL4, Csl4p, hCsl4p, p13, SKI4, Ski4p

Human Chr (Location): 10q24; chr10:97435909-97446011 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(10) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Exosc1 interacts with 119 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process RNA processing, rRNA processing
Component cytoplasm, exosome (RNase complex), ...
Function protein binding, RNA binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (9)    Tissues (1)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 9
cDNA source data(48)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase exosc1    NEW 
Molecular
reagents
All nucleic(50) cDNA(50)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000034321 (Evidence)
Entrez Gene 66583 (Evidence)
UniGene 289086
DFCI TC1584517, TC1582046, TC1670147
NIA Mouse Gene Index U039043
Consensus CDS Project CCDS29816.1, CCDS50436.1
International Mouse Phenotyping Consortium Status Exosc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034321 Ensembl Gene Model | MGI Sequence Detail 10335 C57BL/6J ±  kb
transcript ENSMUST00000075280 Ensembl | MGI Sequence Detail 1622 Not Applicable 
polypeptide ENSMUSP00000074756 Ensembl | MGI Sequence Detail 195 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(12) UniProt(1)
Polymorphisms
SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019495 Exosome complex component CSL4
InterPro IPR025721 Exosome complex component, N-terminal domain
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR022967 RNA-binding domain, S1
Protein Ontology PR:000007257 exosome complex component CSL4
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185743 Cotney J, et al., Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb. Genome Res. 2012 Jun;22(6):1069-80
All references(35)
Other
accession IDs
MGI:1913871, MGI:1914932, MGI:2147537

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory