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Mis18a
Gene Detail
Symbol

Name
ID
Mis18a
MIS18 kinetochore protein homolog A (S. pombe)
MGI:1913828
Synonyms
2610039C10Rik, 2810018N07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 16
51.87 cM, cytoband C3.3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:90719312-90727404 bp, - strand
From VEGA annotation of GRCm38

  8093 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41294  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mis18a

Human
homologs
Human Homolog MIS18A, MIS18 kinetochore protein A
NCBI Gene ID 54069
neXtProt AC  NX_Q9NYP9
Human Synonyms  B28, C21orf45, C21orf46, FASP1, hMis18alpha, MIS18alpha
Human Chr (Location)  21q22.11; chr21:32268219-32279065 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Genomic Mutations involving Mis18a (4)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality between implantation and placentation, reduced growth of the inner cell mass and degeneration, increased apoptosis, decreased DNA methylation, and abnormal mitosis.
 
Interactions
Mis18a interacts with 137 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell cycle, cell division, ...
Component chromosome, chromosome, centromeric region, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (210)    Tissues (136)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 192
RT-PCR 18
cDNA source data(9)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000019967 (Evidence)
Ensembl Gene ModelENSMUSG00000022978 (Evidence)
Entrez Gene66578 (Evidence)
DFCITC1643352, TC1579196
DoTSDT.97405110, DT.492266
NIA Mouse Gene IndexU037289
Consensus CDS ProjectCCDS28316.1
International Mouse Knockout Project StatusMis18a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019967 VEGA Gene Model | MGI Sequence Detail 8093 C57BL/6J ±  kb
transcript OTTMUST00000047582 VEGA | MGI Sequence Detail 1333 Not Applicable 
polypeptide OTTMUSP00000021547 VEGA | MGI Sequence Detail 204 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004910 Yippee-like protein
Protein Ontology PR:000010421 protein Mis18-alpha
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:188023 Kim IS, et al., Roles of Mis18alpha in epigenetic regulation of centromeric chromatin and CENP-A loading. Mol Cell. 2012 May 11;46(3):260-73
All references(34)
Other
accession IDs
MGI:1924304

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory