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Mis18a
Gene Detail
Symbol

Name
ID
Mis18a
MIS18 kinetochore protein homolog A (S. pombe)
MGI:1913828
Synonyms
2610039C10Rik, 2810018N07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 16
51.87 cM, cytoband C3.3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:90719312-90727404 bp, - strand
From VEGA annotation of GRCm38

  8093 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41294  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MIS18A
Gene Tree: Mis18a

Human
homologs
MIS18A, MIS18 kinetochore protein A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 54069
neXtProt AC: NX_Q9NYP9

Human Synonyms: B28, C21orf45, C21orf46, FASP1, hMis18alpha, MIS18alpha

Human Chr (Location): 21q22.11; chr21:32268219-32279065 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
Genomic Mutations involving Mis18a (5)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality between implantation and placentation, reduced growth of the inner cell mass and degeneration, increased apoptosis, decreased DNA methylation, and abnormal mitosis.
 
Interactions
Mis18a interacts with 137 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell cycle, cell division, ...
Component chromosome, chromosome, centromeric region, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (210)    Tissues (136)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 192
RT-PCR 18
cDNA source data(9)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase mis18a    NEW 
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000019967 (Evidence)
Ensembl Gene Model ENSMUSG00000022978 (Evidence)
Entrez Gene 66578 (Evidence)
DFCI TC1579196, TC1643352
DoTS DT.492266, DT.97405110
NIA Mouse Gene Index U037289
Consensus CDS Project CCDS28316.1
International Mouse Phenotyping Consortium Status Mis18a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019967 VEGA Gene Model | MGI Sequence Detail 8093 C57BL/6J ±  kb
transcript OTTMUST00000047582 VEGA | MGI Sequence Detail 1333 Not Applicable 
polypeptide OTTMUSP00000021547 VEGA | MGI Sequence Detail 204 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004910 Yippee/Mis18
Protein Ontology PR:000010421 protein Mis18-alpha
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:188023 Kim IS, et al., Roles of Mis18alpha in epigenetic regulation of centromeric chromatin and CENP-A loading. Mol Cell. 2012 May 11;46(3):260-73
All references(32)
Other
accession IDs
MGI:1924304

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory