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Lars1 Gene Detail
Summary
  • Symbol
    Lars1
  • Name
    leucyl-tRNA synthetase 1
  • Synonyms
    2310045K21Rik, 3110009L02Rik, Lars, mKIAA1352
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913808
    NCBI Gene: 107045
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:42335363-42395259 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 22.37 cM, cytoband E
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    542 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913808
 protein coding gene Chr18:42335363-42395302 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024378
 protein coding gene Chr18:40820721-40882106 (-)
A/J MGP_AJ_G0024345
 protein coding gene Chr18:39413853-39474411 (-)
AKR/J MGP_AKRJ_G0024314
 protein coding gene Chr18:40493190-40558595 (-)
BALB/cJ MGP_BALBcJ_G0024345
 protein coding gene Chr18:39496921-39557698 (-)
C3H/HeJ MGP_C3HHeJ_G0024111
 protein coding gene Chr18:40549130-40616411 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024787
 protein coding gene Chr18:42278925-42344964 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022225
 protein coding gene Chr18:39236949-39301121 (-)
CAST/EiJ MGP_CASTEiJ_G0023586
 protein coding gene Chr18:40505490-40566983 (-)
CBA/J MGP_CBAJ_G0024081
 protein coding gene Chr18:43524220-43598301 (-)
DBA/2J MGP_DBA2J_G0024211
 protein coding gene Chr18:38996096-39057570 (-)
FVB/NJ MGP_FVBNJ_G0024177
 protein coding gene Chr18:38634139-38696996 (-)
LP/J MGP_LPJ_G0024295
 protein coding gene Chr18:40891605-40954529 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024208
 protein coding gene Chr18:44790013-44857665 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024836
 protein coding gene Chr18:40369253-40433706 (-)
PWK/PhJ MGP_PWKPhJ_G0023330
 protein coding gene Chr18:39212392-39271877 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023135
 protein coding gene Chr18:40613174-40678564 (-)
WSB/EiJ MGP_WSBEiJ_G0023649
 protein coding gene Chr18:40279539-40342592 (-)



Homology
more
  • Human Ortholog
    LARS1, leucyl-tRNA synthetase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LARS1, leucyl-tRNA synthetase 1
  • Synonyms
    cLRS, hr025Cl, HSPC192, ILFS1, LARS, LEURS, LEUS, LFIS, LRS, PIG44, RNTLS
  • Links
    NCBI Gene ID: 51520
    neXtProt AC: NX_Q9P2J5
    UniProt: Q9P2J5

  • Chr Location
    5q32; chr5:146110566-146182696 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LARS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1077
  • Tissues
    120
  • cDNA Data
    13
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024493 Ensembl Gene Model | MGI Sequence Detail 59897 C57BL/6J ±  kb
transcript ENSMUST00000097590 Ensembl | MGI Sequence Detail 3980 Not Applicable  
polypeptide ENSMUSP00000095197 Ensembl | MGI Sequence Detail 1178 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000009674 leucine--tRNA ligase, cytoplasmic
    (term hierarchy)
  • EC
    6.1.1.4
  • InterPro Domains
    IPR002300 Aminoacyl-tRNA synthetase, class Ia
    IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
    IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
    IPR004493 Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic
    IPR015413 Methionyl/Leucyl tRNA synthetase
    IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
    IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Molecular
Reagents
less
  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1920310, MGI:2147367
References
more
  • Summaries
    All 46
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:332538 Passarelli MC, et al., Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics. Nat Cell Biol. 2022 Mar;24(3):307-315
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory