About   Help   FAQ
Drap1
Gene Detail
 Symbol
Name
ID
Drap1
Dr1 associated protein 1 (negative cofactor 2 alpha)
MGI:1913806
Synonyms 2310074H19Rik
Feature Type protein coding gene
Genetic Map
Chromosome 19
4.32 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:5422805-5424979 bp, - strand
From VEGA annotation of GRCm38

  2175 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4703  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Drap1

Human
homologs
Human Homolog DRAP1, DR1-associated protein 1 (negative cofactor 2 alpha)
NCBI Gene ID 10589
neXtProt AC  NX_Q14919
Human Synonyms  NC2-alpha
Human Chr (Location)  11q13.3; chr11:65919257-65921577 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
 
Homozygous mutant embryos exhibit development defects including abnormal gastrulation and primitive streak formation.
 
Interactions
Drap1 interacts with 22 markers (Mir32, Mir129-1, Mir129-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process negative regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-templated, ...
Component intracellular, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (37)    Tissues (28)    Images (2)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 23, 28
Assay TypeResults
RNA in situ 29
RT-PCR 8
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021556 (Evidence)
Ensembl Gene ModelENSMUSG00000024914 (Evidence)
Entrez Gene66556 (Evidence)
NIA Mouse Gene IndexU019050
Consensus CDS ProjectCCDS29462.1, CCDS70919.1
International Mouse Knockout Project StatusDrap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021556 VEGA Gene Model | MGI Sequence Detail 2175 C57BL/6J ±  kb
transcript OTTMUST00000051137 VEGA | MGI Sequence Detail 939 Not Applicable 
polypeptide OTTMUSP00000024020 VEGA | MGI Sequence Detail 212 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(4) UniProt(6)
Polymorphisms SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009072 Histone-fold
InterPro IPR003958 Transcription factor CBF/NF-Y/archaeal histone
Protein Ontology PR:000006687 Dr1-associated corepressor
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:186556 Trask MC, et al., Yin-Yang1 is required for epithelial-to-mesenchymal transition and regulation of Nodal signaling during mammalian gastrulation. Dev Biol. 2012 Aug 15;368(2):273-82
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory