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Drap1
Gene Detail
Symbol

Name
ID
Drap1
Dr1 associated protein 1 (negative cofactor 2 alpha)
MGI:1913806
Synonyms
2310074H19Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 19
4.32 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:5422805-5424979 bp, - strand
From VEGA annotation of GRCm38

  2175 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4703  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DRAP1
Gene Tree: Drap1

Human
homologs
DRAP1, DR1-associated protein 1 (negative cofactor 2 alpha)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10589
neXtProt AC: NX_Q14919

Human Synonyms: NC2-alpha

Human Chr (Location): 11q13.3; chr11:65919257-65921577 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
 
Homozygous mutant embryos exhibit development defects including abnormal gastrulation and primitive streak formation.
 
Interactions
Drap1 interacts with 22 markers (Mir32, Mir129-1, Mir129-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (37)    Tissues (28)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
RT-PCR 8
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase drap1 ; ZFIN drap1    NEW 
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000021556 (Evidence)
Ensembl Gene Model ENSMUSG00000024914 (Evidence)
Entrez Gene 66556 (Evidence)
NIA Mouse Gene Index U019050
Consensus CDS Project CCDS29462.1, CCDS70919.1
International Mouse Phenotyping Consortium Status Drap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021556 VEGA Gene Model | MGI Sequence Detail 2175 C57BL/6J ±  kb
transcript OTTMUST00000051137 VEGA | MGI Sequence Detail 939 Not Applicable 
polypeptide OTTMUSP00000024020 VEGA | MGI Sequence Detail 212 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009072 Histone-fold
InterPro IPR003958 Transcription factor CBF/NF-Y/archaeal histone
Protein Ontology PR:000006687 Dr1-associated corepressor
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:186556 Trask MC, et al., Yin-Yang1 is required for epithelial-to-mesenchymal transition and regulation of Nodal signaling during mammalian gastrulation. Dev Biol. 2012 Aug 15;368(2):273-82
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory