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Aggf1 Gene Detail
Summary
  • Symbol
    Aggf1
  • Name
    angiogenic factor with G patch and FHA domains 1
  • Synonyms
    2010009L17Rik, 2310029P06Rik, VG5Q
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913799
    NCBI Gene: 66549
  • Gene Overview
    MyGene.info: AGGF1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:95350683-95375352 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24670 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 49.41 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    AGGF1, angiogenic factor with G-patch and FHA domains 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AGGF1, angiogenic factor with G-patch and FHA domains 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPATC7, GPATCH7, HSU84971, HUS84971, VG5Q
  • Links
    NCBI Gene ID: 55109
    neXtProt AC: NX_Q8N302
    UniProt: Q8N302

  • Chr Location
    5q13.3; chr5:77030385-77065234 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null embryos die before E8.5. Heterozygotes exhibit defective angiogenesis in yolk sacs and embryos and partial lethality. Surviving adults show hemorrhages, increased vascular permeability, and reduced tumor growth of implanted melanoma cell lines.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000030737 VEGA Gene Model | MGI Sequence Detail 24670 C57BL/6J ±  kb
    transcript OTTMUST00000076097 VEGA | MGI Sequence Detail 3249 Not Applicable  
    polypeptide OTTMUSP00000040000 VEGA | MGI Sequence Detail 711 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      141 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 114
      cDNA 113
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2145413, MGI:2447861
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:28008 Harrison SM, et al., Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Development. 1995 Aug;121(8):2479-89
    • Latest
      J:253167 Yao Y, et al., Targeting AGGF1 (angiogenic factor with G patch and FHA domains 1) for Blocking Neointimal Formation After Vascular Injury. J Am Heart Assoc. 2017 Jun 25;6(6)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory