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Cul7
Gene Detail
Symbol

Name
ID
Cul7
cullin 7
MGI:1913765
Synonyms
2510004L20Rik, C230011P08Rik, p185, p193
Feature Type
protein coding gene
Genetic Map
Chromosome 17
22.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:46650337-46664364 bp, + strand
From VEGA annotation of GRCm38

  14028 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56683  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Cul7

Human
homologs
Human Homolog CUL7, cullin 7
NCBI Gene ID 9820
neXtProt AC  NX_Q14999
Human Synonyms  3M1, dJ20C7.5, KIAA0076
Human Chr (Location)  6p21.1; chr6:43037617-43053950 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CUL7
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
During late gestation, homozygous null fetuses display reduced growth associated with abnormal placental development and hemorrhaging due to vascular defects. Mutant mice are born but die shortly after birth, succumbing to respiratory distress.
 
Interactions
Cul7 interacts with 311 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process apoptotic process, epithelial to mesenchymal transition, ...
Component 3M complex, centrosome, ...
Function protein binding, ubiquitin protein ligase binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (77)    Tissues (19)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 61
Western blot 6
RT-PCR 10
cDNA source data(116)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(117) cDNA(116) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024273 (Evidence)
Ensembl Gene ModelENSMUSG00000038545 (Evidence)
Entrez Gene66515 (Evidence)
UniGene329078
DFCITC1611224, TC1670143, TC1602912, TC1596844, TC1592860, TC1602343, TC1577644
DoTSDT.102556709, DT.97414923, DT.97394318, DT.91572481, DT.531351, DT.91431066
NIA Mouse Gene IndexU043608
Consensus CDS ProjectCCDS28833.1
International Mouse Knockout Project StatusCul7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024273 VEGA Gene Model | MGI Sequence Detail 14028 C57BL/6J ±  kb
transcript OTTMUST00000059424 VEGA | MGI Sequence Detail 5530 Not Applicable 
polypeptide OTTMUSP00000028903 VEGA | MGI Sequence Detail 1689 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(2) UniProt(15)
Polymorphisms
SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004939 Anaphase-promoting complex, subunit 10/DOC domain
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR021097 CPH domain
InterPro IPR016157 Cullin, conserved site
InterPro IPR016158 Cullin homology
InterPro IPR001373 Cullin, N-terminal
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR014722 Ribosomal protein L2 domain 2
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000006052 cullin-7
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:197512 Litterman N, et al., An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning. PLoS Biol. 2011 May;9(5):e1001060
All references(43)
Other
accession IDs
MGI:2146763, MGI:2444257

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory