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Tab1 Gene Detail
Summary
  • Symbol
    Tab1
  • Name
    TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • Synonyms
    2310012M03Rik, b2b449Clo, Map3k7ip1, Tak1-binding protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913763
    NCBI Gene: 66513
  • Gene Overview
    MyGene.info: TAB1
Location & Maps
more
  • Sequence Map
    Chr15:80133154-80161701 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28548 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.85 cM, cytoband E2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TAB1, TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TAB1, TGF-beta activated kinase 1 (MAP3K7) binding protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    3'-Tab1, MAP3K7IP1
  • Links
    NCBI Gene ID: 10454
    neXtProt AC: NX_Q15750

  • Chr Location
    22q13.1; chr22:39399754-39437127 (+)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 4 alleles in 4 genetic backgrounds
    21 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    95
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    86
  • Radiation induced
    2
  • Targeted
    5
  • Genomic Mutations
    3 involving Tab1
  • Incidental Mutations
Homozygous mutant fetuses exhibit edema, hemorrhaging, cardiovascular and pulmonary dysmorphogenesis, and die in the late stages of gestation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022414 Ensembl Gene Model | MGI Sequence Detail 28548 C57BL/6J ±  kb
transcript ENSMUST00000023050 Ensembl | MGI Sequence Detail 2931 Not Applicable  
polypeptide ENSMUSP00000023050 Ensembl | MGI Sequence Detail 502 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    178 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001770 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
  • PDB
  • InterPro Domains
    IPR001932 PPM-type phosphatase domain
    IPR015655 Protein phosphatase 2C family
Molecular
Reagents
less
  • All nucleic 36
    cDNA 36

    Microarray probesets 4
Other
Accession IDs
less
MGI:5314038
References
more
  • Summaries
    All 49
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 10
    Phenotypes 35
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory