About   Help   FAQ
Lamtor1
Gene Detail
Symbol

Name
ID
Lamtor1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
MGI:1913758
Synonyms
2400001E08Rik, p18
Feature Type
protein coding gene
Genetic Map
Chromosome 7
54.68 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:101905837-101911903 bp, + strand
From NCBI annotation of GRCm38

  6067 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9909  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lamtor1

Human
homologs
Human Homolog LAMTOR1, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
NCBI Gene ID 55004
neXtProt AC  NX_Q6IAA8
Human Synonyms  C11orf59, p18, p27RF-Rho, PDRO, Ragulator1
Human Chr (Location)  11q13.4; chr11:72097292-72103387 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(32) Targeted(3)
 
Mice homozygous for a knock-out allele exhibit growth arrest and lethality at E7 and abnormal visceral endoderm with abnormal endosome-like organelles and small lysosomes.
 
Interactions
Lamtor1 interacts with 100 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell growth, cellular protein localization, ...
Component endosome, extracellular vesicular exosome, ...
Function guanyl-nucleotide exchange factor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (19)    Tissues (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
Northern blot 15
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000030842 (Evidence)
Entrez Gene66508 (Evidence)
DFCITC1727041, TC1572805, TC1621979
DoTSDT.101319076, DT.94350504, DT.536283, DT.110990528, DT.101709708
Consensus CDS ProjectCCDS21519.1
International Mouse Knockout Project StatusLamtor1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 66508 NCBI Gene Model | MGI Sequence Detail 6067 C57BL/6J ±  kb
transcript NM_025605 RefSeq | MGI Sequence Detail 1201 C57BL/6 
polypeptide Q9CQ22 UniProt | EBI | MGI Sequence Detail 161 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026310 Ragulator complex protein LAMTOR1
Protein Ontology PR:000030559 ragulator complex protein LAMTOR1
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:181222 Takahashi Y, et al., The late endosome/lysosome-anchored p18-mTORC1 pathway controls terminal maturation of lysosomes. Biochem Biophys Res Commun. 2012 Jan 27;417(4):1151-7
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory