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Lamtor1
Gene Detail
Symbol

Name
ID
Lamtor1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
MGI:1913758
Synonyms
2400001E08Rik, p18
Feature Type
protein coding gene
Genetic Map
Chromosome 7
54.68 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:101905904-101926675 bp, + strand
From VEGA annotation of GRCm38

  20772 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9909  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LAMTOR1
Gene Tree: Lamtor1

Human
homologs
LAMTOR1, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55004
neXtProt AC: NX_Q6IAA8

Human Synonyms: C11orf59, p18, p27RF-Rho, PDRO, Ragulator1

Human Chr (Location): 11q13.4; chr11:72097292-72103387 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(34) Targeted(4)
Incidental mutations (data from CvDC )
 
Mice homozygous for a knock-out allele exhibit growth arrest and lethality at E7 and abnormal visceral endoderm with abnormal endosome-like organelles and small lysosomes.
 
Interactions
Lamtor1 interacts with 100 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cell growth, cellular protein localization, ...
Component endosome, extracellular exosome, ...
Function guanyl-nucleotide exchange factor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (19)    Tissues (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
Northern blot 15
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lamtor1    NEW 
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000052219 (Evidence)
Ensembl Gene Model ENSMUSG00000030842 (Evidence)
Entrez Gene 66508 (Evidence)
DFCI TC1621979, TC1727041, TC1572805
DoTS DT.94350504, DT.536283, DT.110990528, DT.101709708, DT.101319076
NIA Mouse Gene Index U008474, U157817, U150227
Consensus CDS Project CCDS21519.1
International Mouse Phenotyping Consortium Status Lamtor1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052219 VEGA Gene Model | MGI Sequence Detail 20772 C57BL/6J ±  kb
transcript OTTMUST00000131197 VEGA | MGI Sequence Detail 1119 Not Applicable 
polypeptide OTTMUSP00000070207 VEGA | MGI Sequence Detail 161 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026310 Ragulator complex protein LAMTOR1
Protein Ontology PR:000030559 ragulator complex protein LAMTOR1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:181222 Takahashi Y, et al., The late endosome/lysosome-anchored p18-mTORC1 pathway controls terminal maturation of lysosomes. Biochem Biophys Res Commun. 2012 Jan 27;417(4):1151-7
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory