About   Help   FAQ
Lamtor1 Gene Detail
Summary
  • Symbol
    Lamtor1
  • Name
    late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
  • Synonyms
    2400001E08Rik, p18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913758
    NCBI Gene: 66508
Location & Maps
more
  • Sequence Map
    Chr7:101905904-101926675 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20772 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.68 cM, cytoband F1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LAMTOR1, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LAMTOR1, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C11orf59, p18, p27RF-Rho, PDRO, Ragulator1
  • Links
    NCBI Gene ID: 55004
    neXtProt AC: NX_Q6IAA8

  • Chr Location
    11q13.4; chr11:72097292-72103387 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    41
  • Chemically induced (other)
    1
  • Gene trapped
    34
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Lamtor1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit growth arrest and lethality at E7 and abnormal visceral endoderm with abnormal endosome-like organelles and small lysosomes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052219 VEGA Gene Model | MGI Sequence Detail 20772 C57BL/6J ±  kb
transcript OTTMUST00000131197 VEGA | MGI Sequence Detail 1119 Not Applicable  
polypeptide OTTMUSP00000070207 VEGA | MGI Sequence Detail 161 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    107 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 6
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 21
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:215643 Zhang CS, et al., The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism. Cell Metab. 2014 Sep 2;20(3):526-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory