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Slc30a7 Gene Detail
Summary
  • Symbol
    Slc30a7
  • Name
    solute carrier family 30 (zinc transporter), member 7
  • Synonyms
    1810059J10Rik, 2610034N15Rik, 4833428C12Rik, ZnT7, ZnT-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913750
    NCBI Gene: 66500
Location & Maps
more
  • Sequence Map
    Chr3:115938973-116007406 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      68434 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC30A7, solute carrier family 30 (zinc transporter), member 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC30A7, solute carrier family 30 (zinc transporter), member 7
    Orthology source: HomoloGene
  • Synonyms
    ZnT-7, ZNT7, ZnTL2
  • Links
    NCBI Gene ID: 148867
    neXtProt AC: NX_Q8NEW0

  • Chr Location
    1p21.2; chr1:100896073-100996913 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Slc30a7
  • Incidental Mutations
Mice homozygous for a gene trapped allele exhibit a low body zinc status, reduced food intake and poor body weight gain, and are lean due to a significant reduction in body fat accumulation; however, no signs of hair growth abnormalities or dermatitis are observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054442 VEGA Gene Model | MGI Sequence Detail 68434 C57BL/6J ±  kb
transcript OTTMUST00000135021 VEGA | MGI Sequence Detail 9020 Not Applicable  
polypeptide OTTMUSP00000071532 VEGA | MGI Sequence Detail 378 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    671 from dbSNP Build 137
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015080 zinc transporter 7
  • InterPro Domains
    IPR002524 Cation efflux protein
    IPR027469 Cation efflux protein transmembrane domain
Molecular
Reagents
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  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1917163, MGI:2139735, MGI:3026979
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:190396 Huang L, et al., Znt7-null mice are more susceptible to diet-induced glucose intolerance and insulin resistance. J Biol Chem. 2012 Sep 28;287(40):33883-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory