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Slc30a7 Gene Detail
Summary
  • Symbol
    Slc30a7
  • Name
    solute carrier family 30 (zinc transporter), member 7
  • Synonyms
    1810059J10Rik, 2610034N15Rik, 4833428C12Rik, ZnT7, ZnT-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913750
    NCBI Gene: 66500
  • Gene Overview
    MyGene.info: SLC30A7
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:115938973-116007406 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 50.16 cM, cytoband G2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    666 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913750
protein coding gene Chr3:115938973-116007414 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027805
protein coding gene Chr3:117807060-117880578 (-)
A/J MGP_AJ_G0027763
protein coding gene Chr3:113949167-114020035 (-)
AKR/J MGP_AKRJ_G0027729
protein coding gene Chr3:116818857-116888138 (-)
BALB/cJ MGP_BALBcJ_G0027775
protein coding gene Chr3:113801760-113869711 (-)
C3H/HeJ MGP_C3HHeJ_G0027506
protein coding gene Chr3:117194818-117265409 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028221
protein coding gene Chr3:122141736-122212873 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025560
protein coding gene Chr3:109648054-109713276 (-)
CAST/EiJ MGP_CASTEiJ_G0026962
protein coding gene Chr3:116465846-116535579 (-)
CBA/J MGP_CBAJ_G0027481
protein coding gene Chr3:126301035-126374999 (-)
DBA/2J MGP_DBA2J_G0027622
protein coding gene Chr3:113187965-113263682 (-)
FVB/NJ MGP_FVBNJ_G0027590
protein coding gene Chr3:110834229-110902126 (-)
LP/J MGP_LPJ_G0027732
protein coding gene Chr3:119347382-119420427 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027620
protein coding gene Chr3:133682888-133753056 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028277
protein coding gene Chr3:116375560-116450866 (-)
PWK/PhJ MGP_PWKPhJ_G0026688
protein coding gene Chr3:112825655-112895396 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026510
protein coding gene Chr3:114387482-114457133 (-)
WSB/EiJ MGP_WSBEiJ_G0027042
protein coding gene Chr3:117052746-117124363 (-)



Homology
more
  • Human Ortholog
    SLC30A7, solute carrier family 30 member 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC30A7, solute carrier family 30 member 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ZnT-7, ZNT7, ZnTL2
  • Links
    NCBI Gene ID: 148867
    neXtProt AC: NX_Q8NEW0
    UniProt: Q8NEW0

  • Chr Location
    1p21.2; chr1:100896076-100996913 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit a low body zinc status, reduced food intake and poor body weight gain, and are lean due to a significant reduction in body fat accumulation; however, no signs of hair growth abnormalities or dermatitis are observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054414 Ensembl Gene Model | MGI Sequence Detail 68434 C57BL/6J ±  kb
    transcript ENSMUST00000067485 Ensembl | MGI Sequence Detail 9020 Not Applicable  
    polypeptide ENSMUSP00000065254 Ensembl | MGI Sequence Detail 378 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917163, MGI:2139735, MGI:3026979
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:264002 Huang L, et al., Aberrant fatty acid metabolism in skeletal muscle contributes to insulin resistance in zinc transporter 7 (znt7)-knockout mice. J Biol Chem. 2018 May 18;293(20):7549-7563

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory