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Slc30a7 Gene Detail
Summary
  • Symbol
    Slc30a7
  • Name
    solute carrier family 30 (zinc transporter), member 7
  • Synonyms
    1810059J10Rik, 2610034N15Rik, 4833428C12Rik, ZnT7, ZnT-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913750
    NCBI Gene: 66500
  • Gene Overview
    MyGene.info: SLC30A7
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:115938973-116007406 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      68434 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 50.16 cM, cytoband G2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SLC30A7, solute carrier family 30 member 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC30A7, solute carrier family 30 member 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ZnT-7, ZNT7, ZnTL2
  • Links
    NCBI Gene ID: 148867
    neXtProt AC: NX_Q8NEW0
    UniProt: Q8NEW0

  • Chr Location
    1p21.2; chr1:100896076-100996913 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit a low body zinc status, reduced food intake and poor body weight gain, and are lean due to a significant reduction in body fat accumulation; however, no signs of hair growth abnormalities or dermatitis are observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000054442 VEGA Gene Model | MGI Sequence Detail 68434 C57BL/6J ±  kb
    transcript OTTMUST00000135021 VEGA | MGI Sequence Detail 9020 Not Applicable  
    polypeptide OTTMUSP00000071532 VEGA | MGI Sequence Detail 378 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      666 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917163, MGI:2139735, MGI:3026979
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:248923 Tepaamorndech S, et al., Zinc transporter 7 deficiency affects lipid synthesis in adipocytes by inhibiting insulin-dependent Akt activation and glucose uptake. FEBS J. 2016 Jan;283(2):378-94

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory