Ndufb3 MGI Mouse Gene Detail - MGI:1913745 - NADH:ubiquinone oxidoreductase subunit B3

Symbol

Ndufb3
Name

NADH:ubiquinone oxidoreductase subunit B3
Synonyms

2700033I16Rik

Feature Type

protein coding gene
IDs

MGI:1913745
NCBI Gene: 66495
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:58625556-58635123 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 29.13 cM
Mapping Data

2 experiments

SNPs within 2kb

276 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913745	protein coding gene	Chr1:58625543-58635123 (+)
129S1/SvImJ	ENSMUSG00200018405	protein coding gene	Chr1:56129140-56138738 (+)
A/J	ENSMUSG00195027109	protein coding gene	Chr1:55662368-55671955 (+)
AKR/J	ENSMUSG00220036033	protein coding gene	Chr1:55752528-55762121 (+)
BALB/cJ	ENSMUSG00180013742	protein coding gene	Chr1:55910174-55919760 (+)
C3H/HeJ	ENSMUSG00175001012	protein coding gene	Chr1:56039867-56049455 (+)
C57BL/6NJ	ENSMUSG00215019187	protein coding gene	Chr1:55971646-55981229 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014168	protein coding gene	Chr1:52349916-52359154 (+)
CAST/EiJ	ENSTCUG00005013081	protein coding gene	Chr1:55814401-55823646 (+)
CBA/J	ENSMUSG00210034932	protein coding gene	Chr1:55720342-55729593 (+)
DBA/2J	ENSMUSG00185054876	protein coding gene	Chr1:56840035-56849286 (+)
FVB/NJ	ENSMUSG00205012586	protein coding gene	Chr1:55685697-55695285 (+)
JF1/MsJ	ENSUMUG00000030769	protein coding gene	Chr1:55815991-55825220 (+)
LP/J	ENSMUSG00230025865	protein coding gene	Chr1:56849689-56859287 (+)
NOD/ShiLtJ	ENSMUSG00190030584	protein coding gene	Chr1:55891340-55900918 (+)
NZO/HlLtJ	ENSMUSG00225008438	protein coding gene	Chr1:60048332-60057582 (+)
PWK/PhJ	ENSLUMG00010023650	protein coding gene	Chr1:55349878-55359110 (+)
SPRET/EiJ	ENSMSPG00010022546	protein coding gene	Chr1:57199161-57208402 (+)
WSB/EiJ	ENSIUOG00005019090	protein coding gene	Chr1:55516356-55525938 (+)

Human Ortholog

NDUFB3, NADH:ubiquinone oxidoreductase subunit B3

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NDUFB3, NADH:ubiquinone oxidoreductase subunit B3
Synonyms

B12, CI-B12, MC1DN25
Links

HGNC:7698

NCBI Gene ID: 4709

UniProt: O43676
Chr Location

2q33.1; chr2:201071433-201085754 (+) GRCh38

MGI Vertebrate Homology

Ndufb3 stringent orthology
1 human;1 mouse;4 rat;1 zebrafish
HCOP

vertebrate homology predictions: NDUFB3
Gene Tree

Ndufb3

Diseases

1 with human NDUFB3 associations

				Human Disease	Mouse Models
				nuclear type mitochondrial complex I deficiency 25 IDs nuclear type mitochondrial complex I deficiency 25 DOID:0112067 OMIM:618246

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

6
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Ndufb3
Incidental Mutations

APF
Find Mice (IMSR)

9 strains or lines available

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All GO Annotations

17
GO References

12

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

691
Tissues

94
cDNA Data

92
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ndufb3

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS14977.1

Ensembl

ENSMUSG00000026032 (Evidence)
NCBI Gene

66495

			Length	Strain/Species	Flank
genomic	66495	NCBI Gene Model \| MGI Sequence Detail	9568	C57BL/6J	± kb
transcript	NM_025597	RefSeq \| MGI Sequence Detail	769	C57BL/6
polypeptide	Q9CQZ6	UniProt \| EBI \| MGI Sequence Detail	104	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011087 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

(term hierarchy)
PDB

6G2J, 6G72, 6ZR2, 6ZTQ, 7AK5, 7AK6, 7B93, 7PSA, 8C2S, 8CA3, 8CA5, 8IAO, 8IAQ, 8IB4, 8IB6, 8IB9, 8IBB, 8IBD, 8IBF, 8IC2, 8IC4, 8OLT, 8OM1, 8PW5, 8PW6, 8PW7, 8RGP, 8RGQ, 8RGR, 8RGT, 8UCA
InterPro Domains

IPR012576 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
GlyGen

Q9CQZ6 1 site, 1 O-linked glycan (1 site)

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All nucleic 92

cDNA 92

Antibodies 1

Microarray probesets 3

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MGI:2144808

Summaries

All 55

Developmental Gene Expression 4

Gene Ontology 12

Phenotypes 13
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:370467 Gauberg J, et al., Spinal motor neuron development and metabolism are transcriptionally regulated by nuclear factor IA. Sci Adv. 2025 Aug;11(31):eadu3346

TSS for Ndufb3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6781	Chr1:58625540-58625560 (+)	-6 bp
Tssr6782	Chr1:58625564-58625605 (+)	29 bp
Tssr6783	Chr1:58625750-58625784 (+)	211 bp
Tssr93	Chr1:58625787-58625800 (+)	238 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24