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Acot11
Gene Detail
 Symbol
Name
ID
Acot11
acyl-CoA thioesterase 11
MGI:1913736
Synonyms 1110020M10Rik, 2010309H15Rik, BFIT1, MGC:25974, mKIAA0707, Thea, Them1
Feature Type protein coding gene
Genetic Map
Chromosome 4
49.75 cM, cytoband C7
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:106744555-106804998 bp, - strand
From VEGA annotation of GRCm38

  60444 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11977  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Acot11

Human
homologs
Human Homolog ACOT11, acyl-CoA thioesterase 11
NCBI Gene ID 26027
neXtProt AC  NX_Q8WXI4
Human Synonyms  BFIT, STARD14, THEA, THEM1
Human Chr (Location)  1p32.3; chr1:54548134-54634744 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display resistance to high fat diet induced obesity, inflammation and hepatic steatosis, increased energy expenditure, increased brown adipose tissue amount, and increased food intake.
 
Interactions
Acot11 interacts with 336 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process fatty acid metabolic process, intracellular signal transduction
Component cytoplasm, extracellular vesicular exosome, ...
Function 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity, 2-oxoglutaryl-CoA thioesterase activity, ...
External Resources: FuncBase
Expression
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000008201 (Evidence)
Ensembl Gene ModelENSMUSG00000034853 (Evidence)
Entrez Gene329910 (Evidence)
NIA Mouse Gene IndexU025333
EC3.1.2.-
Consensus CDS ProjectCCDS18426.1
International Mouse Knockout Project StatusAcot11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008201 VEGA Gene Model | MGI Sequence Detail 60444 C57BL/6J ±  kb
transcript OTTMUST00000018623 VEGA | MGI Sequence Detail 2939 Not Applicable 
polypeptide OTTMUSP00000008557 VEGA | MGI Sequence Detail 614 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(6) UniProt(10)
Polymorphisms SNPs within 2kb(638 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002913 START domain
InterPro IPR023393 START-like domain
InterPro IPR006683 Thioesterase superfamily
Protein Ontology PR:000003634 acyl-coenzyme A thioesterase 11
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190632 Han S, et al., Functional characterization of thioesterase superfamily member 1/Acyl-CoA thioesterase 11: implications for metabolic regulation. J Lipid Res. 2012 Dec;53(12):2620-31
All references(35)
Other
accession IDs
MGI:1915900, MGI:2140551

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory