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Acot11
Gene Detail
Symbol

Name
ID
Acot11
acyl-CoA thioesterase 11
MGI:1913736
Synonyms
1110020M10Rik, 2010309H15Rik, BFIT1, MGC:25974, mKIAA0707, Thea, Them1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
49.75 cM, cytoband C7
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:106744555-106804998 bp, - strand
From VEGA annotation of GRCm38

  60444 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11977  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ACOT11
Gene Tree: Acot11

Human
homologs
ACOT11, acyl-CoA thioesterase 11
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 26027
neXtProt AC: NX_Q8WXI4

Human Synonyms: BFIT, STARD14, THEA, THEM1

Human Chr (Location): 1p32.3; chr1:54548134-54634744 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Genomic Mutations involving Acot11 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display resistance to high fat diet induced obesity, inflammation and hepatic steatosis, increased energy expenditure, increased brown adipose tissue amount, and increased food intake.
 
Interactions
Acot11 interacts with 335 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase acot11 ; ZFIN acot11a, acot11b    NEW 
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000008201 (Evidence)
Ensembl Gene Model ENSMUSG00000034853 (Evidence)
Entrez Gene 329910 (Evidence)
NIA Mouse Gene Index U025333
EC 3.1.2.-
Consensus CDS Project CCDS18426.1
International Mouse Phenotyping Consortium Status Acot11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008201 VEGA Gene Model | MGI Sequence Detail 60444 C57BL/6J ±  kb
transcript OTTMUST00000018623 VEGA | MGI Sequence Detail 2939 Not Applicable 
polypeptide OTTMUSP00000008557 VEGA | MGI Sequence Detail 614 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(8) UniProt(10)
Polymorphisms
SNPs within 2kb(638 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029069 HotDog domain
InterPro IPR002913 START domain
InterPro IPR023393 START-like domain
InterPro IPR006683 Thioesterase superfamily
Protein Ontology PR:000003634 acyl-coenzyme A thioesterase 11
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190632 Han S, et al., Functional characterization of thioesterase superfamily member 1/Acyl-CoA thioesterase 11: implications for metabolic regulation. J Lipid Res. 2012 Dec;53(12):2620-31
All references(34)
Other
accession IDs
MGI:1915900, MGI:2140551

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory