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Nmnat1 Gene Detail
Summary
  • Symbol
    Nmnat1
  • Name
    nicotinamide nucleotide adenylyltransferase 1
  • Synonyms
    2610529L11Rik, 5730441G13Rik, D4Cole1e, nicotinamide mononucleotide adenylyl transferase, nmnat
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913704
    NCBI Gene: 66454
  • Gene Overview
    MyGene.info: NMNAT1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:149468597-149485180 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 79.47 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    152 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913704
protein coding gene Chr4:149467572-149485202 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029140
protein coding gene Chr4:153312201-153333222 (-)
A/J MGP_AJ_G0029105
protein coding gene Chr4:146920430-146939080 (-)
AKR/J MGP_AKRJ_G0029053
protein coding gene Chr4:150941946-150959547 (-)
BALB/cJ MGP_BALBcJ_G0029121
protein coding gene Chr4:147421178-147440237 (-)
C3H/HeJ MGP_C3HHeJ_G0028842
protein coding gene Chr4:151499012-151516915 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029570
protein coding gene Chr4:158850828-158869443 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026816
protein coding gene Chr4:139336094-139352690 (-)
CAST/EiJ MGP_CASTEiJ_G0028255
protein coding gene Chr4:148732512-148750105 (-)
CBA/J MGP_CBAJ_G0028804
protein coding gene Chr4:163516328-163537973 (-)
DBA/2J MGP_DBA2J_G0028953
protein coding gene Chr4:147023591-147041169 (-)
FVB/NJ MGP_FVBNJ_G0028917
protein coding gene Chr4:146135164-146153743 (-)
LP/J MGP_LPJ_G0029043
protein coding gene Chr4:153235450-153253390 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028944
protein coding gene Chr4:166753481-166771309 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029602
protein coding gene Chr4:151440761-151460843 (-)
PWK/PhJ MGP_PWKPhJ_G0027975
protein coding gene Chr4:143026944-143044901 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027809
protein coding gene Chr4:145681587-145701095 (-)
WSB/EiJ MGP_WSBEiJ_G0028335
protein coding gene Chr4:151594135-151611678 (-)



Homology
more
  • Human Ortholog
    NMNAT1, nicotinamide nucleotide adenylyltransferase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NMNAT1, nicotinamide nucleotide adenylyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LCA9, NMNAT, PNAT1
  • Links
    NCBI Gene ID: 64802
    neXtProt AC: NX_Q9HAN9
    UniProt: Q9HAN9

  • Chr Location
    1p36.22; chr1:9942923-9996739 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Nmnat1 mouse models; 1 with human NMNAT1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 4 alleles in 4 genetic backgrounds
    122 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete prenatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66454 NCBI Gene Model | MGI Sequence Detail 16584 C57BL/6J ±  kb
    transcript NM_001356357 RefSeq | MGI Sequence Detail 2408 C57BL/6  
    polypeptide NP_001343286 RefSeq | MGI Sequence Detail 285 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 24

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917803, MGI:1927087
    References
    more
    • Summaries
      All 156
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 5
      Phenotypes 122
    • Earliest
      J:19951 Lunn ER, et al., Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve. Eur J Neurosci. 1989 Jan;1(1):27-33
    • Latest
      J:261467 Ryu KW, et al., Metabolic regulation of transcription through compartmentalized NAD(+) biosynthesis. Science. 2018 May 11;360(6389)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory