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Nmnat1
Gene Detail
 Symbol
Name
ID
Nmnat1
nicotinamide nucleotide adenylyltransferase 1
MGI:1913704
Synonyms 2610529L11Rik, 5730441G13Rik, D4Cole1e, nicotinamide mononucleotide adenylyl transferase, nmnat
Feature Type protein coding gene
Genetic Map
Chromosome 4
79.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:149467572-149485202 bp, - strand
From VEGA annotation of GRCm38

  17631 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:39074  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Nmnat1

Human
homologs
Human Homolog NMNAT1, nicotinamide nucleotide adenylyltransferase 1
NCBI Gene ID 64802
neXtProt AC  NX_Q9HAN9
Human Synonyms  LCA9, NMNAT, PNAT1
Human Chr (Location)  1p36.22; chr1:9943428-9985498 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human NMNAT1
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(19) Spontaneous(1) Targeted(4)
Genomic Mutations involving Nmnat1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit complete prenatal lethality.
 
Interactions
Nmnat1 interacts with 197 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process NAD biosynthetic process, response to wounding
Component nucleus
Function nicotinamide-nucleotide adenylyltransferase activity, nicotinate-nucleotide adenylyltransferase activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(1) cDNA(23)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000010262 (Evidence)
Ensembl Gene ModelENSMUSG00000028992 (Evidence)
Entrez Gene66454 (Evidence)
UniGene76062
Consensus CDS ProjectCCDS18960.1
International Mouse Knockout Project StatusNmnat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010262 VEGA Gene Model | MGI Sequence Detail 17631 C57BL/6J ±  kb
transcript OTTMUST00000023867 VEGA | MGI Sequence Detail 1238 Not Applicable 
polypeptide OTTMUSP00000010940 VEGA | MGI Sequence Detail 285 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(5)
Polymorphisms SNPs within 2kb(167 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000011290 nicotinamide mononucleotide adenylyltransferase 1
References (Earliest) J:65178 Conforti L, et al., A Ufd2/D4Cole1e chimeric protein and overexpression of rbp7 in the slow wallerian degeneration (WldS) mouse. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11377-82
(Latest) J:200901 Gilley J, et al., Rescue of Peripheral and CNS Axon Defects in Mice Lacking NMNAT2. J Neurosci. 2013 Aug 14;33(33):13410-24
All references(45)
Other
accession IDs
MGI:1917803, MGI:1927087

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory