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Pam16 Gene Detail
Summary
  • Symbol
    Pam16
  • Name
    presequence translocase-asssociated motor 16 homolog (S. cerevisiae)
  • Synonyms
    2010110I09Rik, CGI-136, Magmas, Tim16
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913699
    NCBI Gene: 66449
Location & Maps
more
  • Genetic Map
    Chromosome 16, 2.45 cM
  • Mapping Data
    2 experiments
Homology
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  • Human Ortholog
    PAM16, presequence translocase associated motor 16 homolog
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PAM16, presequence translocase associated motor 16 homolog
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CGI-136, MAGMAS, SMDMDM, TIM16, TIMM16
  • Links
    NCBI Gene ID: 51025
    neXtProt AC: NX_Q9Y3D7

  • Chr Location
    16p13.3; chr16:4340251-4351372 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 41100
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PAM16
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PAM16 associations

Human Disease Mouse Models
       Spondylometaphyseal Dysplasia, Megarbane-Dagher-Melki Type; SMDMDM   OMIM: 613320
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    30
  • Gene trapped
    27
  • Targeted
    3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026710 VEGA Gene Model | MGI Sequence Detail 8525 C57BL/6J ±  kb
transcript OTTMUST00000066083 VEGA | MGI Sequence Detail 596 Not Applicable  
polypeptide OTTMUSP00000033048 VEGA | MGI Sequence Detail 125 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    87 from dbSNP Build 142
Protein
Information
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  • Protein Ontology
    PR:000016343 mitochondrial import inner membrane translocase subunit Tim16
Molecular
Reagents
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  • All nucleic 6
    cDNA 6

    Microarray probesets 4
Other
Accession IDs
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MGI:2143773
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory