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Spc25 Gene Detail
Summary
  • Symbol
    Spc25
  • Name
    SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
  • Synonyms
    2600017H08Rik, 2610205L13Rik, Spbc25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913692
    NCBI Gene: 66442
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:69193895-69206194 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 39.64 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913692
protein coding gene Chr2:69193895-69206213 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025795
protein coding gene Chr2:69126080-69139636 (-)
A/J MGP_AJ_G0025772
protein coding gene Chr2:66468173-66480963 (-)
AKR/J MGP_AKRJ_G0025741
protein coding gene Chr2:68260185-68277158 (-)
BALB/cJ MGP_BALBcJ_G0025767
protein coding gene Chr2:66646384-66660209 (-)
C3H/HeJ MGP_C3HHeJ_G0025527
protein coding gene Chr2:68487340-68502617 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026214
protein coding gene Chr2:71220734-71234272 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023617
protein coding gene Chr2:63710766-63721879 (-)
CAST/EiJ MGP_CASTEiJ_G0024991
protein coding gene Chr2:68588378-68602599 (-)
CBA/J MGP_CBAJ_G0025507
protein coding gene Chr2:73815300-73830081 (-)
DBA/2J MGP_DBA2J_G0025638
protein coding gene Chr2:66112330-66124600 (-)
FVB/NJ MGP_FVBNJ_G0025601
protein coding gene Chr2:65482664-65499916 (-)
LP/J MGP_LPJ_G0025727
protein coding gene Chr2:68988802-69003256 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025630
protein coding gene Chr2:75882797-75896736 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026271
protein coding gene Chr2:68344930-68357743 (-)
PWK/PhJ MGP_PWKPhJ_G0024732
protein coding gene Chr2:65941576-65954054 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024539
protein coding gene Chr2:68575566-68590663 (-)
WSB/EiJ MGP_WSBEiJ_G0025059
protein coding gene Chr2:68766905-68780429 (-)



Homology
more
  • Human Ortholog
    SPC25, SPC25 component of NDC80 kinetochore complex
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPC25, SPC25 component of NDC80 kinetochore complex
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AD024, hSpc25, SPBC25
  • Links
    NCBI Gene ID: 57405
    neXtProt AC: NX_Q9HBM1
    UniProt: Q9HBM1

  • Chr Location
    2q24.3; chr2:168865045-168890443 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41387
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SPC25
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005233 Ensembl Gene Model | MGI Sequence Detail 12300 C57BL/6J ±  kb
transcript ENSMUST00000112320 Ensembl | MGI Sequence Detail 1527 Not Applicable  
polypeptide ENSMUSP00000107939 Ensembl | MGI Sequence Detail 226 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 4
Other
Accession IDs
less
MGI:1919740
References
more
  • Summaries
    All 37
    Developmental Gene Expression 6
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:241850 Naiman N, et al., Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 May 22;41(4):349-365.e3

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory