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Fis1 Gene Detail
Summary
  • Symbol
    Fis1
  • Name
    fission, mitochondrial 1
  • Synonyms
    2010003O14Rik, Ttc11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913687
    NCBI Gene: 66437
  • Gene Overview
    MyGene.info: FIS1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:136953275-136966234 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 76.06 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913687
protein coding gene Chr5:136953264-136966234 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030210
protein coding gene Chr5:141654822-141668023 (+)
A/J MGP_AJ_G0030178
protein coding gene Chr5:135523410-135537041 (+)
AKR/J MGP_AKRJ_G0030111
protein coding gene Chr5:139916155-139928883 (+)
BALB/cJ MGP_BALBcJ_G0030188
protein coding gene Chr5:136885428-136898169 (+)
C3H/HeJ MGP_C3HHeJ_G0029904
protein coding gene Chr5:140536881-140549618 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030640
protein coding gene Chr5:146932015-146947003 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027861
protein coding gene Chr5:129808638-129813158 (+)
CAST/EiJ MGP_CASTEiJ_G0029314
protein coding gene Chr5:139951834-139965838 (+)
CBA/J MGP_CBAJ_G0029874
protein coding gene Chr5:152659827-152675691 (+)
DBA/2J MGP_DBA2J_G0030025
protein coding gene Chr5:135419244-135431979 (+)
FVB/NJ MGP_FVBNJ_G0029980
protein coding gene Chr5:134597061-134610205 (+)
LP/J MGP_LPJ_G0030114
protein coding gene Chr5:142093381-142107935 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030012
protein coding gene Chr5:155570015-155583447 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030681
protein coding gene Chr5:139741153-139753875 (+)
PWK/PhJ MGP_PWKPhJ_G0029027
protein coding gene Chr5:134507236-134520254 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028863
protein coding gene Chr5:137332476-137345859 (+)
WSB/EiJ MGP_WSBEiJ_G0029387
protein coding gene Chr5:140484620-140500443 (+)



Homology
more
  • Human Ortholog
    FIS1, fission, mitochondrial 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FIS1, fission, mitochondrial 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGI-135, TTC11
  • Links
    NCBI Gene ID: 51024
    neXtProt AC: NX_Q9Y3D6
    UniProt: Q9Y3D6

  • Chr Location
    7q22.1; chr7:101239612-101245090 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019054 Ensembl Gene Model | MGI Sequence Detail 12960 C57BL/6J ±  kb
transcript ENSMUST00000019198 Ensembl | MGI Sequence Detail 786 Not Applicable  
polypeptide ENSMUSP00000019198 Ensembl | MGI Sequence Detail 152 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007527 mitochondrial fission 1 protein
  • PDB
  • InterPro Domains
    IPR028061 Fis1, C-terminal tetratricopeptide repeat
    IPR028058 Fis1, N-terminal tetratricopeptide repeat
    IPR016543 Mitochondria fission 1 protein
    IPR033745 Mitochondria fission protein Fis1, cytosolic domain
    IPR011990 Tetratricopeptide-like helical domain superfamily
Molecular
Reagents
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  • All nucleic 136
    cDNA 136

    Microarray probesets 4
References
more
  • Summaries
    All 48
    Developmental Gene Expression 4
    Gene Ontology 12
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:239181 Rojansky R, et al., Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1. Elife. 2016 Nov 17;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory