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Fis1 Gene Detail
Summary
  • Symbol
    Fis1
  • Name
    fission, mitochondrial 1
  • Synonyms
    2010003O14Rik, Ttc11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913687
    NCBI Gene: 66437
  • Gene Overview
    MyGene.info: FIS1
Location & Maps
more
  • Sequence Map
    Chr5:136953275-136966234 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12960 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 76.06 cM, cytoband G1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FIS1, fission, mitochondrial 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FIS1, fission, mitochondrial 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CGI-135, TTC11
  • Links
    NCBI Gene ID: 51024
    neXtProt AC: NX_Q9Y3D6

  • Chr Location
    7q22.1; chr7:101239612-101245090 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    55
  • Gene trapped
    51
  • Targeted
    4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023394 VEGA Gene Model | MGI Sequence Detail 12960 C57BL/6J ±  kb
transcript OTTMUST00000056794 VEGA | MGI Sequence Detail 786 Not Applicable  
polypeptide OTTMUSP00000027340 VEGA | MGI Sequence Detail 152 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    80 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007527 mitochondrial fission 1 protein
  • PDB
  • InterPro Domains
    IPR028061 Fis1, C-terminal tetratricopeptide repeat
    IPR028058 Fis1, N-terminal tetratricopeptide repeat
    IPR016543 Mitochondria fission 1 protein
    IPR011990 Tetratricopeptide-like helical domain
Molecular
Reagents
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  • All nucleic 135
    cDNA 135

    Microarray probesets 4
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Gene Ontology 10
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:226977 Moriya M, et al., Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype. Hum Mol Genet. 2015 Dec 20;24(25):7349-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory