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Coprs Gene Detail
Summary
  • Symbol
    Coprs
  • Name
    coordinator of PRMT5, differentiation stimulator
  • Synonyms
    1700029I03Rik, 2410022L05Rik, COPR5, MGC11316
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913673
    NCBI Gene: 66423
Location & Maps
more
  • Sequence Map
    Chr8:13884794-13890281 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5488 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 6.41 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    COPRS, coordinator of PRMT5 and differentiation stimulator
  • Vertebrate Orthologs
    7
  • Human Ortholog
    COPRS, coordinator of PRMT5 and differentiation stimulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C17orf79, COPR5, HSA272196, TTP1
  • Links
    NCBI Gene ID: 55352
    neXtProt AC: NX_Q9NQ92

  • Chr Location
    17q11.2; chr17:31851865-31859307 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    2
  • Targeted
    6
Mice homozygous for a knock-out allele exhibit reduced retroperitoneal white adipose tissue with fewer and larger adipocytes. In vitro adipogenic conversion of embryoid bodies and primary embryonic fibroblasts is markedly delayed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060790 VEGA Gene Model | MGI Sequence Detail 5488 C57BL/6J ±  kb
transcript OTTMUST00000148608 VEGA | MGI Sequence Detail 793 Not Applicable  
polypeptide OTTMUSP00000077230 VEGA | MGI Sequence Detail 173 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    56 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000041220 coordinator of PRMT5 and differentiation stimulator
  • InterPro Domains
    IPR029289 Coordinator of PRMT5 and differentiation stimulator
Molecular
Reagents
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  • All nucleic 35
    cDNA 35

    Microarray probesets 7
Other
Accession IDs
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MGI:1916725, MGI:2142413, MGI:2142487, MGI:2142866
References
more
  • Summaries
    All 31
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:221154 Paul C, et al., The Wnt-target gene Dlk-1 is regulated by the Prmt5-associated factor Copr5 during adipogenic conversion. Biol Open. 2015;4(3):312-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory