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Coprs Gene Detail
Summary
  • Symbol
    Coprs
  • Name
    coordinator of PRMT5, differentiation stimulator
  • Synonyms
    1700029I03Rik, 2410022L05Rik, COPR5, MGC11316
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913673
    NCBI Gene: 66423
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:13884794-13890281 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5488 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 6.41 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    COPRS, coordinator of PRMT5 and differentiation stimulator
  • Vertebrate Orthologs
    7
  • Human Ortholog
    COPRS, coordinator of PRMT5 and differentiation stimulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C17orf79, COPR5, HSA272196, TTP1
  • Links
    NCBI Gene ID: 55352
    neXtProt AC: NX_Q9NQ92
    UniProt: Q9NQ92

  • Chr Location
    17q11.2; chr17:31851865-31859307 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced retroperitoneal white adipose tissue with fewer and larger adipocytes. In vitro adipogenic conversion of embryoid bodies and primary embryonic fibroblasts is markedly delayed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060790 VEGA Gene Model | MGI Sequence Detail 5488 C57BL/6J ±  kb
transcript OTTMUST00000148608 VEGA | MGI Sequence Detail 793 Not Applicable  
polypeptide OTTMUSP00000077230 VEGA | MGI Sequence Detail 173 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    56 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000041220 coordinator of PRMT5 and differentiation stimulator
  • InterPro Domains
    IPR029289 Coordinator of PRMT5 and differentiation stimulator
Molecular
Reagents
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  • All nucleic 36
    cDNA 35
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:1916725, MGI:2142413, MGI:2142487, MGI:2142866
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:244597 Cui W, et al., Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Sci Rep. 2016 Nov 21;6(None):37396

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory