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Polr2e Gene Detail
Summary
  • Symbol
    Polr2e
  • Name
    polymerase (RNA) II (DNA directed) polypeptide E
  • Synonyms
    25kDa, RPB5, XAP4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913670
    NCBI Gene: 66420
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79871787-79875493 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    199 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913670
 protein coding gene Chr10:79871783-79875629 (-)
129S1/SvImJ ENSMUSG00200042772
 protein coding gene Chr10:76489821-76511096 (-)
A/J ENSMUSG00195040169
 protein coding gene Chr10:76885357-76906633 (-)
AKR/J ENSMUSG00220043284
 protein coding gene Chr10:76482912-76504194 (-)
BALB/cJ ENSMUSG00180048399
 protein coding gene Chr10:76895843-76917119 (-)
C3H/HeJ ENSMUSG00175052107
 protein coding gene Chr10:76766554-76787828 (-)
C57BL/6NJ ENSMUSG00215050073
 protein coding gene Chr10:76508253-76529525 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015561
 protein coding gene Chr10:74018860-74023125 (-)
CAST/EiJ ENSTCUG00005045877
 protein coding gene Chr10:76393199-76414406 (-)
CBA/J ENSMUSG00210040203
 protein coding gene Chr10:76622625-76643901 (-)
DBA/2J ENSMUSG00185044024
 protein coding gene Chr10:76965013-76986289 (-)
FVB/NJ ENSMUSG00205040096
 protein coding gene Chr10:76677801-76699074 (-)
JF1/MsJ ENSUMUG00000028218
 protein coding gene Chr10:78195674-78216693 (-)
LP/J ENSMUSG00230046696
 protein coding gene Chr10:78734743-78756017 (-)
NOD/ShiLtJ ENSMUSG00190034137
 protein coding gene Chr10:76878745-76900020 (-)
NZO/HlLtJ ENSMUSG00225050684
 protein coding gene Chr10:83021098-83042372 (-)
PWK/PhJ ENSLUMG00010042084
 protein coding gene Chr10:76554925-76576693 (-)
SPRET/EiJ ENSMSPG00010037997
 protein coding gene Chr10:78181431-78185167 (-)
WSB/EiJ ENSIUOG00005050751
 protein coding gene Chr10:76583202-76604284 (-)



Homology
more
  • Human Ortholog
    POLR2E, RNA polymerase II, I and III subunit E
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLR2E, RNA polymerase II, I and III subunit E
  • Synonyms
    hRPB25, hsRPB5, RPABC1, RPB5, XAP4
  • Links
    NCBI Gene ID: 5434
    UniProt: P19388

  • Chr Location
    19p13.3; chr19:1085104-1095389 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    129
  • cDNA Data
    151
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66420 NCBI Gene Model | MGI Sequence Detail 3707 C57BL/6J ±  kb
    transcript NM_025554 RefSeq | MGI Sequence Detail 1022 FVB/N  
    polypeptide Q80UW8 UniProt | EBI | MGI Sequence Detail 210 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000012991 DNA-directed RNA polymerases I, II, and III subunit RPABC1
      (term hierarchy)
    • InterPro Domains
      IPR014381 DNA-directed RNA polymerase subunit Rpo5/Rpb5
      IPR005571 RNA polymerase, Rpb5, N-terminal
      IPR036710 RNA polymerase Rpb5, N-terminal domain superfamily
      IPR020608 RNA polymerase, subunit H/Rpb5, conserved site
      IPR000783 RNA polymerase, subunit H/Rpb5 C-terminal
      IPR035913 RPB5-like RNA polymerase subunit superfamily
    • GlyGen
      Q80UW8 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 152
      cDNA 151
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2143824
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory