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Polr2e Gene Detail
Summary
  • Symbol
    Polr2e
  • Name
    polymerase (RNA) II (DNA directed) polypeptide E
  • Synonyms
    25kDa, RPB5, XAP4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913670
    NCBI Gene: 66420
  • Gene Overview
    MyGene.info: POLR2E
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80035953-80039659 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913670
protein coding gene Chr10:80035949-80039795 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017479
protein coding gene Chr10:80611135-80614981 (-)
A/J MGP_AJ_G0017457
protein coding gene Chr10:77793482-77797328 (-)
AKR/J MGP_AKRJ_G0017418
protein coding gene Chr10:79914555-79918401 (-)
BALB/cJ MGP_BALBcJ_G0017419
protein coding gene Chr10:78020188-78024034 (-)
C3H/HeJ MGP_C3HHeJ_G0017242
protein coding gene Chr10:80018954-80022800 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017873
protein coding gene Chr10:83394427-83398273 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015561
protein coding gene Chr10:74018860-74023125 (-)
CAST/EiJ MGP_CASTEiJ_G0016809
protein coding gene Chr10:80216425-80220265 (-)
CBA/J MGP_CBAJ_G0017214
protein coding gene Chr10:86623399-86627245 (-)
DBA/2J MGP_DBA2J_G0017320
protein coding gene Chr10:77008646-77012492 (-)
FVB/NJ MGP_FVBNJ_G0017314
protein coding gene Chr10:76189256-76193102 (-)
LP/J MGP_LPJ_G0017391
protein coding gene Chr10:81087684-81091530 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017340
protein coding gene Chr10:88581804-88585650 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017914
protein coding gene Chr10:79898708-79902554 (-)
PWK/PhJ MGP_PWKPhJ_G0016590
protein coding gene Chr10:76875809-76879689 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016379
protein coding gene Chr10:78873729-78877841 (-)
WSB/EiJ MGP_WSBEiJ_G0016869
protein coding gene Chr10:79926580-79930426 (-)



Homology
more
  • Human Ortholog
    POLR2E, RNA polymerase II subunit E
  • Vertebrate Orthologs
    10
  • Human Ortholog
    POLR2E, RNA polymerase II subunit E
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hRPB25, hsRPB5, RPABC1, RPB5, XAP4
  • Links
    NCBI Gene ID: 5434
    neXtProt AC: NX_P19388
    UniProt: P19388

  • Chr Location
    19p13.3; chr19:1086579-1095392 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66420 NCBI Gene Model | MGI Sequence Detail 3707 C57BL/6J ±  kb
transcript NM_025554 RefSeq | MGI Sequence Detail 1022 FVB/N  
polypeptide Q80UW8 UniProt | EBI | MGI Sequence Detail 210 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000012991 DNA-directed RNA polymerases I, II, and III subunit RPABC1
  • InterPro Domains
    IPR020609 Archaeal RpoH /eukaryotic RPB5 RNA polymerase subunit
    IPR014381 DNA-directed RNA polymerase RPB5 subunit, eukaryote/virus
    IPR005571 RNA polymerase, Rpb5, N-terminal
    IPR036710 RNA polymerase Rpb5, N-terminal domain superfamily
    IPR020608 RNA polymerase, subunit H/Rpb5, conserved site
    IPR000783 RNA polymerase, subunit H/Rpb5 C-terminal
    IPR035913 RPB5-like RNA polymerase subunit superfamily
Molecular
Reagents
less
  • All nucleic 152
    cDNA 151
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2143824
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory