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Tbcb Gene Detail
Summary
  • Symbol
    Tbcb
  • Name
    tubulin folding cofactor B
  • Synonyms
    2410007D12Rik, Ckap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913661
    NCBI Gene: 66411
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:29923554-29931622 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 17.33 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    380 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913661
 protein coding gene Chr7:29923554-29931697 (-)
129S1/SvImJ ENSMUSG00200040439
 protein coding gene Chr7:19705152-19713295 (-)
A/J ENSMUSG00195037233
 protein coding gene Chr7:22380887-22388859 (-)
AKR/J ENSMUSG00220043568
 protein coding gene Chr7:22098557-22106528 (+)
BALB/cJ ENSMUSG00180015006
 protein coding gene Chr7:20440359-20448331 (-)
C3H/HeJ ENSMUSG00175027282
 protein coding gene Chr7:21512248-21520388 (-)
C57BL/6NJ ENSMUSG00215054646
 protein coding gene Chr7:19614361-19622505 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029506
 protein coding gene Chr7:29471512-29479476 (-)
CAST/EiJ ENSTCUG00005038432
 protein coding gene Chr7:21419830-21427431 (-)
CBA/J ENSMUSG00210024934
 protein coding gene Chr7:20674866-20683009 (-)
DBA/2J ENSMUSG00185041554
 protein coding gene Chr7:23771540-23779511 (-)
FVB/NJ ENSMUSG00205010368
 protein coding gene Chr7:20423882-20432024 (-)
JF1/MsJ ENSUMUG00000035475
 protein coding gene Chr7:28217779-28225754 (-)
LP/J ENSMUSG00230052030
 protein coding gene Chr7:28942018-28949989 (-)
NOD/ShiLtJ ENSMUSG00190007682
 protein coding gene Chr7:20104729-20112867 (-)
NZO/HlLtJ ENSMUSG00225024146
 protein coding gene Chr7:27781971-27790110 (-)
PWK/PhJ ENSLUMG00010020248
 protein coding gene Chr7:20145473-20153392 (-)
SPRET/EiJ ENSMSPG00010040235
 protein coding gene Chr7:19509796-19517755 (-)
WSB/EiJ ENSIUOG00005050753
 protein coding gene Chr7:14393430-14401339 (-)



Homology
more
  • Human Ortholog
    TBCB, tubulin folding cofactor B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBCB, tubulin folding cofactor B
  • Synonyms
    CG22, CKAP1, CKAPI
  • Links
    NCBI Gene ID: 1155
    UniProt: Q99426

  • Chr Location
    19q13.12; chr19:36114289-36125947 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    660
  • Tissues
    29
  • cDNA Data
    146
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66411 NCBI Gene Model | MGI Sequence Detail 8069 C57BL/6J ±  kb
transcript NM_025548 RefSeq | MGI Sequence Detail 1343 C57BL/6  
polypeptide Q9D1E6 UniProt | EBI | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 147
    cDNA 146
    Other 1
    Antibodies 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142150
References
more
  • Summaries
    All 45
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 13
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory