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Sac3d1 Gene Detail
Summary
  • Symbol
    Sac3d1
  • Name
    SAC3 domain containing 1
  • Synonyms
    2410004C24Rik, Shd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913656
    NCBI Gene: 66406
  • Gene Overview
    MyGene.info: SAC3D1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6116004-6118586 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913656
protein coding gene Chr19:6116004-6118586 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024749
protein coding gene Chr19:3146639-3149221 (-)
A/J MGP_AJ_G0024715
protein coding gene Chr19:2978641-2981223 (-)
AKR/J MGP_AKRJ_G0024688
protein coding gene Chr19:3066624-3069206 (-)
BALB/cJ MGP_BALBcJ_G0024715
protein coding gene Chr19:2970323-2972905 (-)
C3H/HeJ MGP_C3HHeJ_G0024483
protein coding gene Chr19:3085401-3087983 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025161
protein coding gene Chr19:3207322-3209904 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022595
protein coding gene Chr19:2903842-2906884 (-)
CAST/EiJ MGP_CASTEiJ_G0023955
protein coding gene Chr19:3097031-3099619 (-)
CBA/J MGP_CBAJ_G0024455
protein coding gene Chr19:3365250-3367832 (-)
DBA/2J MGP_DBA2J_G0024582
protein coding gene Chr19:2965562-2968144 (-)
FVB/NJ MGP_FVBNJ_G0024548
protein coding gene Chr19:2976336-2978918 (-)
LP/J MGP_LPJ_G0024668
protein coding gene Chr19:3123208-3125790 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024577
protein coding gene Chr19:3184032-3186614 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025209
protein coding gene Chr19:3096865-3099447 (-)
PWK/PhJ MGP_PWKPhJ_G0023701
protein coding gene Chr19:2994710-2997297 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023506
protein coding gene Chr19:3054036-3056640 (-)
WSB/EiJ MGP_WSBEiJ_G0024017
protein coding gene Chr19:3104078-3106660 (-)



Homology
more
  • Human Ortholog
    SAC3D1, SAC3 domain containing 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SAC3D1, SAC3 domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSU79266, SHD1
  • Links
    NCBI Gene ID: 29901
    UniProt: A6NKF1

  • Chr Location
    11q13.1; chr11:65040904-65044828 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice heterozygote for a null allele had increased numbers of myeloid and erythroid progenitor cells. Mice homozygote for a null allele had these features plus mild spleen and thymus hyperplasia, an increased T cell proliferative response, and enhanced IgM secretion by B cells to IL-5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66406 NCBI Gene Model | MGI Sequence Detail 2583 C57BL/6J ±  kb
    transcript NM_133678 RefSeq | MGI Sequence Detail 1374 C57BL/6  
    polypeptide A6H687 UniProt | EBI | MGI Sequence Detail 427 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR000717 Proteasome component (PCI) domain
      IPR005062 SAC3/GANP/THP3
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2147639
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory