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Asf1a Gene Detail
Summary
  • Symbol
    Asf1a
  • Name
    anti-silencing function 1A histone chaperone
  • Synonyms
    2310079C17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913653
    NCBI Gene: 66403
  • Gene Overview
    MyGene.info: ASF1A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:53596961-53609225 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12265 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 27.24 cM, cytoband B3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ASF1A, anti-silencing function 1A histone chaperone
  • Vertebrate Orthologs
    12
  • Human Ortholog
    ASF1A, anti-silencing function 1A histone chaperone
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGI-98, CIA, HSPC146
  • Links
    NCBI Gene ID: 25842
    neXtProt AC: NX_Q9Y294
    UniProt: Q9Y294

  • Chr Location
    6q22.31; chr6:118894077-118909171 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8528
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;3 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ASF1A
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele die at midgestation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66403 NCBI Gene Model | MGI Sequence Detail 12265 C57BL/6J ±  kb
    transcript NM_025541 RefSeq | MGI Sequence Detail 2192 C57BL/6  
    polypeptide Q9CQE6 UniProt | EBI | MGI Sequence Detail 204 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      57 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2143923
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 20
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory