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Asf1a Gene Detail
Summary
  • Symbol
    Asf1a
  • Name
    anti-silencing function 1A histone chaperone
  • Synonyms
    2310079C17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913653
    NCBI Gene: 66403
  • Gene Overview
    MyGene.info: ASF1A
Location & Maps
more
  • Sequence Map
    Chr10:53596961-53609213 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12253 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 27.24 cM, cytoband B3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ASF1A, anti-silencing function 1A histone chaperone
  • Vertebrate Orthologs
    12
  • Human Ortholog
    ASF1A, anti-silencing function 1A histone chaperone
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CGI-98, CIA, HSPC146
  • Links
    NCBI Gene ID: 25842
    neXtProt AC: NX_Q9Y294

  • Chr Location
    6q22.31; chr6:118894077-118909171 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8528
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;3 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: ASF1A
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    69
  • Chemically induced (other)
    1
  • Gene trapped
    65
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Asf1a
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a gene trap allele die at midgestation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019857 Ensembl Gene Model | MGI Sequence Detail 12253 C57BL/6J ±  kb
transcript ENSMUST00000020004 Ensembl | MGI Sequence Detail 2180 Not Applicable  
polypeptide ENSMUSP00000020004 Ensembl | MGI Sequence Detail 204 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    57 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004367 histone chaperone ASF1A
  • InterPro Domains
    IPR006818 Histone chaperone ASF1-like
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 5
Other
Accession IDs
less
MGI:2143923
References
more
  • Summaries
    All 44
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 19
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory