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Sln Gene Detail
Summary
  • Symbol
    Sln
  • Name
    sarcolipin
  • Synonyms
    2310045A07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913652
    NCBI Gene: 66402
  • Gene Overview
    MyGene.info: SLN
Location & Maps
more
  • Sequence Map
    Chr9:53850251-53853844 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3594 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 29.24 cM, cytoband C
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLN, sarcolipin
  • Human Ortholog
    SLN, sarcolipin
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 6588
    neXtProt AC: NX_O00631

  • Chr Location
    11q22.3; chr11:107707375-107712061 (-)  GRCh38.p2

  • HCOP
    human homology predictions: SLN
  • Protein SuperFamily
  • Gene Tree
    Sln
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    3
  • Targeted
    7
  • Transgenic
    1
  • Incidental Mutations
    APF
Mice homozygous for a null allele exhibit increased cardiac contractility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042045 Ensembl Gene Model | MGI Sequence Detail 3594 C57BL/6J ±  kb
transcript ENSMUST00000048485 Ensembl | MGI Sequence Detail 515 Not Applicable  
polypeptide ENSMUSP00000036950 Ensembl | MGI Sequence Detail 31 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    32 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR008028 Sarcolipin
Molecular
Reagents
less
  • All nucleic 54
    cDNA 51
    Primer pair 3

    Microarray probesets 4
References
more
  • Summaries
    All 44
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 18
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:231350 Shimura D, et al., Heterozygous deletion of sarcolipin maintains normal cardiac function. Am J Physiol Heart Circ Physiol. 2016 Jan 1;310(1):H92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory