About   Help   FAQ
Sar1b Gene Detail
Summary
  • Symbol
    Sar1b
  • Name
    secretion associated Ras related GTPase 1B
  • Synonyms
    2310075M17Rik, 2900019I22Rik, Sara2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913647
    NCBI Gene: 66397
  • Gene Overview
    MyGene.info: SAR1B
Location & Maps
more
  • Sequence Map
    Chr11:51763687-51791925 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28239 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 31.41 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SAR1B, secretion associated Ras related GTPase 1B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SAR1B, secretion associated Ras related GTPase 1B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ANDD, CMRD, GTBPB, SARA2
  • Links
    NCBI Gene ID: 51128
    neXtProt AC: NX_Q9Y6B6

  • Chr Location
    5q31.1; chr5:134601149-134632843 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SAR1B associations

Human Disease Mouse Models
       Chylomicron Retention Disease; CMRD   OMIM: 246700
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    34
  • Chemically induced (other)
    1
  • Gene trapped
    30
  • Targeted
    3
  • Genomic Mutations
    1 involving Sar1b
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005609 VEGA Gene Model | MGI Sequence Detail 28239 C57BL/6J ±  kb
transcript OTTMUST00000012480 VEGA | MGI Sequence Detail 1201 Not Applicable  
polypeptide OTTMUSP00000005778 VEGA | MGI Sequence Detail 198 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    97 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014455 GTP-binding protein SAR1b
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR006689 Small GTPase superfamily, ARF/SAR type
    IPR006687 Small GTPase superfamily, SAR1-type
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
less
  • All nucleic 130
    cDNA 130

    Microarray probesets 4
Other
Accession IDs
less
MGI:1920195
References
more
  • Summaries
    All 33
    Gene Ontology 2
    Phenotypes 14
  • Earliest
    J:15964 Shen KA, et al., Molecular analysis of SAR1-related cDNAs from a mouse pituitary cell line. FEBS Lett. 1993 Dec 13;335(3):380-5
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory