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Iscu
Gene Detail
 Symbol
Name
ID
Iscu
IscU iron-sulfur cluster scaffold homolog (E. coli)
MGI:1913633
Synonyms 2310020H20Rik, Nifun
Feature Type protein coding gene
Genetic Map
Chromosome 5
55.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:113772748-113778288 bp, + strand
From VEGA annotation of GRCm38

  5541 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6991  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Iscu

Human
homologs
Human Homolog ISCU, iron-sulfur cluster assembly enzyme
NCBI Gene ID 23479
neXtProt AC  NX_Q9H1K1
Human Synonyms  2310020H20Rik, HML, hnifU, ISU2, NIFU, NIFUN
Human Chr (Location)  12q24.1; chr12:108561463-108569384 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ISCU
Alleles
and
phenotypes
All alleles(2) : Targeted(1) Gene trapped(1)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process iron-sulfur cluster assembly
Component cytoplasm, cytosol, ...
Function iron ion binding, iron-sulfur cluster binding, ...
External Resources: FuncBase
Expression
cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000025818 (Evidence)
Ensembl Gene ModelENSMUSG00000025825 (Evidence)
Entrez Gene66383 (Evidence)
DFCITC1576742
DoTSDT.536530, DT.94247150
NIA Mouse Gene IndexU006018, U019011
PDB1WFZ
Consensus CDS ProjectCCDS19553.1
International Mouse Knockout Project StatusIscu
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025818 VEGA Gene Model | MGI Sequence Detail 5541 C57BL/6J ±  kb
transcript OTTMUST00000063603 VEGA | MGI Sequence Detail 1395 Not Applicable 
polypeptide OTTMUSP00000031462 VEGA | MGI Sequence Detail 209 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(2) UniProt(6)
Polymorphisms SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011339 ISC system FeS cluster assembly, IscU scaffold
InterPro IPR002871 NIF system FeS cluster assembly, NifU, N-terminal
Protein Ontology PR:000009113 iron-sulfur cluster assembly enzyme ISCU, mitochondrial
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:198599 La P, et al., Mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation stabilizes ISCU protein: implications for iron metabolism. J Biol Chem. 2013 May 3;288(18):12901-9
All references(35)
Other
accession IDs
MGI:2147429

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory