About   Help   FAQ
Iscu
Gene Detail
Symbol

Name
ID
Iscu
IscU iron-sulfur cluster scaffold homolog (E. coli)
MGI:1913633
Synonyms
2310020H20Rik, Nifun
Feature Type
protein coding gene
Genetic Map
Chromosome 5
55.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:113772748-113778288 bp, + strand
From VEGA annotation of GRCm38

  5541 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6991  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: ISCU
Gene Tree: Iscu

Human
homologs
ISCU, iron-sulfur cluster assembly enzyme
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 23479
neXtProt AC: NX_Q9H1K1

Human Synonyms: 2310020H20Rik, HML, hnifU, ISU2, NIFU, NIFUN

Human Chr (Location): 12q24.1; chr12:108561463-108569384 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ISCU

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Interactions
Iscu interacts with 112 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process [2Fe-2S] cluster assembly, cellular iron ion homeostasis, ...
Component cytoplasm, cytosol, ...
Function 2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, ...
External Resources: FuncBase
Expression
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase iscu    NEW 
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000025818 (Evidence)
Ensembl Gene Model ENSMUSG00000025825 (Evidence)
Entrez Gene 66383 (Evidence)
DFCI TC1576742
DoTS DT.536530, DT.94247150
NIA Mouse Gene Index U019011, U006018
PDB 1WFZ
Consensus CDS Project CCDS19553.1
International Mouse Phenotyping Consortium Status Iscu
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025818 VEGA Gene Model | MGI Sequence Detail 5541 C57BL/6J ±  kb
transcript OTTMUST00000063603 VEGA | MGI Sequence Detail 1395 Not Applicable 
polypeptide OTTMUSP00000031462 VEGA | MGI Sequence Detail 209 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011339 ISC system FeS cluster assembly, IscU scaffold
InterPro IPR002871 NIF system FeS cluster assembly, NifU, N-terminal
Protein Ontology PR:000009113 iron-sulfur cluster assembly enzyme ISCU, mitochondrial
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:198599 La P, et al., Mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation stabilizes ISCU protein: implications for iron metabolism. J Biol Chem. 2013 May 3;288(18):12901-9
All references(35)
Other
accession IDs
MGI:2147429

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory