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Iscu Gene Detail
Summary
  • Symbol
    Iscu
  • Name
    iron-sulfur cluster assembly enzyme
  • Synonyms
    2310020H20Rik, Nifun
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913633
    NCBI Gene: 66383
  • Gene Overview
    MyGene.info: ISCU
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:113772812-113778282 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.55 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913633
protein coding gene Chr5:113772748-113778288 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029923
protein coding gene Chr5:116450729-116456272 (+)
A/J MGP_AJ_G0029888
protein coding gene Chr5:111889666-111898953 (+)
AKR/J MGP_AKRJ_G0029826
protein coding gene Chr5:115438826-115445920 (+)
BALB/cJ MGP_BALBcJ_G0029899
protein coding gene Chr5:113262065-113267616 (+)
C3H/HeJ MGP_C3HHeJ_G0029619
protein coding gene Chr5:115929678-115936771 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030353
protein coding gene Chr5:120971061-120976650 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027581
protein coding gene Chr5:106719265-106724474 (+)
CAST/EiJ MGP_CASTEiJ_G0029027
protein coding gene Chr5:114852727-114858055 (+)
CBA/J MGP_CBAJ_G0029586
protein coding gene Chr5:125532302-125539163 (+)
DBA/2J MGP_DBA2J_G0029736
protein coding gene Chr5:111955006-111960765 (+)
FVB/NJ MGP_FVBNJ_G0029693
protein coding gene Chr5:110728157-110742898 (+)
LP/J MGP_LPJ_G0029825
protein coding gene Chr5:117020676-117028818 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029724
protein coding gene Chr5:130037191-130044167 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030394
protein coding gene Chr5:114890747-114897492 (+)
PWK/PhJ MGP_PWKPhJ_G0028741
protein coding gene Chr5:110580413-110585888 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028579
protein coding gene Chr5:112420548-112425839 (+)
WSB/EiJ MGP_WSBEiJ_G0029103
protein coding gene Chr5:115451549-115460130 (+)



Homology
more
  • Human Ortholog
    ISCU, iron-sulfur cluster assembly enzyme
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ISCU, iron-sulfur cluster assembly enzyme
    Orthology source: HomoloGene, HGNC
  • Synonyms
    2310020H20Rik, HML, hnifU, ISU2, NIFU, NIFUN
  • Links
    NCBI Gene ID: 23479
    neXtProt AC: NX_Q9H1K1
    UniProt: Q9H1K1

  • Chr Location
    12q23.3; chr12:108561463-108569384 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6991
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ISCU
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Iscu
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66383 NCBI Gene Model | MGI Sequence Detail 5471 C57BL/6J ±  kb
transcript NM_001363317 RefSeq | MGI Sequence Detail 1056 C57BL/6  
polypeptide Q9D7P6 UniProt | EBI | MGI Sequence Detail 168 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000009113 iron-sulfur cluster assembly enzyme ISCU, mitochondrial
  • PDB
  • InterPro Domains
    IPR011339 ISC system FeS cluster assembly, IscU scaffold
    IPR002871 NIF system FeS cluster assembly, NifU, N-terminal
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147429
References
more
  • Summaries
    All 42
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:264015 Roy AR, et al., The transcriptional regulator CCCTC-binding factor limits oxidative stress in endothelial cells. J Biol Chem. 2018 Jun 1;293(22):8449-8461

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory