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Rtca Gene Detail
Summary
  • Symbol
    Rtca
  • Name
    RNA 3'-terminal phosphate cyclase
  • Synonyms
    2310009A18Rik, Rtcd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913618
    NCBI Gene: 66368
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:116488963-116508203 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 50.35 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913618
protein coding gene Chr3:116488963-116508208 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027810
protein coding gene Chr3:118390439-118409722 (-)
A/J MGP_AJ_G0027768
protein coding gene Chr3:114514476-114533567 (-)
AKR/J MGP_AKRJ_G0027734
protein coding gene Chr3:117420976-117441853 (-)
BALB/cJ MGP_BALBcJ_G0027780
protein coding gene Chr3:114359270-114378754 (-)
C3H/HeJ MGP_C3HHeJ_G0027511
protein coding gene Chr3:117772606-117791915 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028226
protein coding gene Chr3:122732651-122751863 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025565
protein coding gene Chr3:110207601-110226814 (-)
CAST/EiJ MGP_CASTEiJ_G0026967
protein coding gene Chr3:117061599-117080994 (-)
CBA/J MGP_CBAJ_G0027486
protein coding gene Chr3:126931256-126953008 (-)
DBA/2J MGP_DBA2J_G0027627
protein coding gene Chr3:113751014-113770603 (-)
FVB/NJ MGP_FVBNJ_G0027595
protein coding gene Chr3:111389654-111409053 (-)
LP/J MGP_LPJ_G0027737
protein coding gene Chr3:119940094-119960390 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027625
protein coding gene Chr3:134305434-134324229 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028282
protein coding gene Chr3:116948661-116968490 (-)
PWK/PhJ MGP_PWKPhJ_G0026693
protein coding gene Chr3:113401050-113420746 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026515
protein coding gene Chr3:114973052-114996874 (-)
WSB/EiJ MGP_WSBEiJ_G0027047
protein coding gene Chr3:117643130-117661843 (-)



Homology
more
  • Human Ortholog
    RTCA, RNA 3'-terminal phosphate cyclase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RTCA, RNA 3'-terminal phosphate cyclase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RPC, RTC1, RTCD1
  • Links
    NCBI Gene ID: 8634
    neXtProt AC: NX_O00442
    UniProt: O00442

  • Chr Location
    1p21.2; chr1:100266158-100292769 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele exhibit incomplete prenatal lethality and enhanced retinal ganglion cell axon regeneration after optic nerve crush injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66368 NCBI Gene Model | MGI Sequence Detail 19241 C57BL/6J ±  kb
    transcript NM_025517 RefSeq | MGI Sequence Detail 1576 C57BL/6  
    polypeptide Q9D7H3 UniProt | EBI | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000014338 RNA 3'-terminal phosphate cyclase
    • EC
    • InterPro Domains
      IPR000228 RNA 3'-terminal phosphate cyclase
      IPR023797 RNA 3'-terminal phosphate cyclase domain
      IPR037136 RNA 3'-terminal phosphate cyclase domain superfamily
      IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta
      IPR013791 RNA 3'-terminal phosphate cyclase, insert domain
      IPR036553 RNA 3'-terminal phosphate cyclase, insert domain superfamily
      IPR020719 RNA 3'-terminal phosphate cyclase-like, conserved site
      IPR017770 RNA 3'-terminal phosphate cyclase type 1
    Molecular
    Reagents
    less
    • All nucleic 79
      cDNA 76
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139716
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:233466 Song Y, et al., Regulation of axon regeneration by the RNA repair and splicing pathway. Nat Neurosci. 2015 Jun;18(6):817-25

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory